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MMP9 — OSM

Text-mined interactions from Literome

Li et al., J Immunol 2001 : We have previously shown that OSM induces MMP and tissue inhibitor of metalloproteinase-3 ( TIMP-3 ) gene expression in chondrocytes by protein tyrosine kinase dependent mechanisms ... In the present study, we investigated signaling pathways regulating the induction of MMP and TIMP-3 genes by OSM ... Curcumin also inhibited OSM induced MMP-1, MMP-3 , MMP-13, and TIMP-3 gene expression ... Thus, OSM induces MMP and TIMP-3 genes in chondrocytes by activating JAK/STAT and mitogen activated protein kinase signaling cascades, and interference with these pathways may be a useful approach to block the catabolic actions of OSM
Nagata et al., Arterioscler Thromb Vasc Biol 2003 : Thus, we sought to investigate whether OSM regulates MMP-9 expression in cultured rat aortic smooth muscle cells ( SMCs ) and, if so, to determine the signaling pathway for MMP-9 induction by OSM ... A MEK1 inhibitor, PD98059, not only blocked ERK1/2 phosphorylation but also abolished the OSM induced MMP-9 upregulation, whereas the MMP-9 induction was not affected by overexpressing dominant negative STAT3 ... OSM upregulates MMP-9 expression in SMCs through the MEK-ERK but not STAT3 pathway
Hui et al., Arthritis Rheum 2003 (Osteoarthritis, Knee) : The in vivo data clearly indicated that OSM + TNFalpha overexpression increased MMP levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) ... Specifically, OSM + TNFalpha induced marked synovial hyperplasia, inflammation, and cartilage and bone destruction with a concomitant increase in MMP expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage
Chen et al., Glia 2006 (Astrocytoma...) : However, OSM does not affect the invasive capacity of the astroglioma cells, which may be due to the divergent effects of OSM on MMP-2 and MMP-9 expression
Sondergaard et al., Osteoarthritis Cartilage 2006 : TNF-alpha and OSM induced a pronounced increase in matrix metalloproteinase ( MMP ) activity, which was strongly inhibited by calcitonin
Ouyang et al., Biomed Res 2006 (Lung Neoplasms...) : OSM also reduced the adhesion and invasion ability of 95-D cells and inhibited the secretion of MMP-2 and MMP-9 in OSM treated cells
Tiffen et al., Mol Endocrinol 2008 : OSM also promoted the expression of metalloproteinases MMP3, MMP12 , and MMP14, which, in vitro, were responsible for OSM-specific apoptosis
Izumi-Yoneda et al., Mol Hum Reprod 2009 (Fetal Membranes, Premature Rupture) : After stimulation with oncostatin M (OSM), interleukin-6 (IL-6) or tumor necrotic factor alpha (TNF alpha), hAE cells increased the expression of AAT, while the expression of MMP9 was reduced by OSM and induced by TNF alpha
Litherland et al., J Biol Chem 2010 : However, MMP1 and MMP13 induction by IL-1 + OSM was inhibited only by aPKC silencing, suggesting that only atypical isoforms play a significant role in complex inflammatory milieus
Ko et al., Placenta 2012 : We found that OSM enhanced the constitutive RNA and protein expressions of MMP-2 and MMP-9 in HTR8SVneo cell lines