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MMP9 — OCLN

Text-mined interactions from Literome

Behzadian et al., Invest Ophthalmol Vis Sci 2001 : Both TGF-beta and MMP-9 increased the permeability of BRE monolayers and reduced the levels of the junction protein occludin
Lohmann et al., Brain Res 2004 : PAO induced occludin proteolysis could be prevented by different MMP inhibitors
Reijerkerk et al., FASEB J 2006 : Diapedesis of monocytes is associated with MMP mediated occludin disappearance in brain endothelial cells
Huang et al., FASEB J 2009 : Indeed, the HIV induced decrease in the expression of JAM-A and occludin was restored by inhibition of MMP activity
Liu et al., J Neurochem 2009 (Infarction, Middle Cerebral Artery...) : Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9 mediated occludin degradation in focal cerebral ischemia ... Inhibition of MMP-9 by NBO or MMP-inhibitor, BB1101, significantly reduced occludin protein loss in ischemic microvessels ... These results suggest that NBO attenuates early BBB disruption, and inhibition of MMP-9 mediated occludin degradation is an important mechanism for this protection
Lischper et al., Brain Res 2010 : MMP inhibition by the metalloproteinase inhibitor GM6001 prevented occludin degradation and reduced the intercellular gap formation
Tu et al., Neurochem Res 2011 (Brain Edema...) : Our study suggested that baicalin reduces MCAO induced neuronal damage, brain edema and BBB permeability, which might be associated with the inhibition of MMP-9 expression and MMP-9 mediated occludin degradation
Liu et al., J Neurosci 2012 (Brain Ischemia...) : These data indicate that cerebral ischemia initiates two rapid parallel processes, MMP-2 mediated occludin degradation and Cav-1 mediated claudin-5 redistribution, to cause BBB disruption at early stroke stages relevant to acute thrombolysis
Jin et al., Exp Neurol 2013 (Brain Ischemia...) : Our results show that NBO plus minocycline effectively reduces brain injury in transient focal cerebral ischemia with protection due to inhibition on MMP-2/9 mediated occludin degradation and attenuation of caspase dependent and independent apoptotic pathways