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CXCL12 — MMP9

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MMP9 → CXCL12 (increases) Chinni et al., Prostate 2006*
  Evidence: exogenous CXCL12 induced Akt1 phosphorylation exogenous CXCL12 induced MMP-9 expression by PC cells
• OpenBEL Selventa BEL large corpus: MMP9 → CXCL12 (increases, CXCL12 Activity)
  Evidence: We found that Slit also inhibits CXCL12-induced phosphatidylinositol 3-kinase, p44/42 MAP kinase, and metalloproteinase 2 and 9 activities.

Text-mined interactions from Literome

Kollet et al., J Clin Invest 2003 : Irradiation or inflammation increased SDF-1 levels and hepatic injury induced MMP-9 activity, leading to both increased CXCR4 expression and SDF-1 mediated recruitment of hematopoietic progenitors to the liver
Yu et al., J Bone Miner Res 2003 (Bone Resorption) : SDF-1 versus RANKL effects on chemotaxis, transcollagen migration, MMP-9 expression and activity, OC development, and bone resorption were evaluated in RAW cells or RAW-OCs ... Both SDF-1 and RANKL increased MMP-9 , a matrix degrading enzyme essential for OC precursor migration into developing bone marrow cavities, and increased transcollagen migration of RAW cells in a MMP dependent manner
Samara et al., Cancer Lett 2004 (Carcinoma, Squamous Cell...) : CXCL12 also increased the active matrix metalloproteinase (MMP)-9 secreted
Petit et al., J Clin Invest 2005 (Burkitt Lymphoma) : SDF-1 induced proliferation and MMP-9 secretion also required PKC-zeta activation
Zhang et al., Carcinogenesis 2005 (Glioblastoma...) : We found that SDF-1alpha increased the expression of membrane type-2 matrix metalloproteinase ( MT2-MMP ), but not the other MT-MMPs, MMP-2 or MMP-9
Chinni et al., Prostate 2006 (Bone Neoplasms...) : CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells : the role of bone microenvironment associated CXCL12 ... Here we showed that ( a ) CXCL12/CXCR4 axis is expressed in PC bone metastasis ; ( b ) exogenous CXCL12 induced MMP-9 expression by PC cells ; ( c ) bone stromal cells and bone tissue conditioned media induced the migration of PC cells in a CXCR4 dependent manner ; ( d ) pharmacological inhibition of PI3 kinase and MAP kinase pathways abrogated CXCL12 induced MMP-9 expression and invasion of PC cells ; ( e ) exogenous CXCL12 induced Akt1 phosphorylation is indispensable for proMMP-9 secretion, migration, and invasion of PC cells ; ( f ) CXCR4 was localized to lipid rafts in PC cells and initiated Akt phosphorylation
Brule et al., Glycobiology 2006 : Moreover, SDF-1 increases the matrix metalloproteinase-9 (MMP-9) mRNA level as well as MMP-9 activity in HeLa cells, and MMP-9 silencing by RNA interference strongly decreases the syndecan-1 and -4 ectodomain shedding accelerated by SDF-1
Redondo-Muñoz et al., Blood 2006 (Leukemia, B-Cell...) : The chemokine CXCL12 also up-regulated MMP-9 , independently of alpha4beta1 and involving ERK1/2 but not Akt activity
Ries et al., Blood 2007 (Inflammation) : Moreover, the inflammatory cytokines TGF-beta1, IL-1beta, and TNF-alpha up-regulated MMP-2, MT1-MMP, and/or MMP-9 production in these cells, resulting in a strong stimulation of chemotactic migration through ECM, whereas the chemokine SDF-1alpha exhibited minor effects on MMP/TIMP expression and cell invasion
Tang et al., Carcinogenesis 2008 (Lung Neoplasms...) : Furthermore, mitogen activated protein kinase kinase inhibitor PD98059 suppressed SDF-1alpha induced MMP-9 mRNA expression ... Transient transfection with dominant negative extracellular signal regulated kinase ( ERK ) mutant also showed that the ERK signaling pathway was involved in SDF-1alpha induced MMP-9 expression
Yuecheng et al., Eur J Cancer Prev 2007 (Neoplasm Invasiveness...) : Moreover, SDF-1-CXCR4 interaction activated MMP-9 at the both transcription and protein levels and MMP-2 only at the post-translation level
Shirvaikar et al., Cytotherapy 2008 : Finally, we observed that SDF-1 up-regulated the expression of both MMP-9 and MT1-MMP in CB CD34 ( + ) cells and ex vivo expanded CFU-Meg
Hu et al., Cancer Sci 2008 (Neoplasm Invasiveness...) : Furthermore, in contrast to CXCL12, which enhanced the activity of matrix metalloproteinase (MMP) 9 and MMP2 in PC3 and LNCap, CXCL16 ligation resulted in stronger MMP9 and MMP2 activity in LNCap but not in PC3
Zhou et al., Hum Reprod 2008 : CXCL12 induced an apparent increase in the invasiveness of trophoblasts ( P < 0.01 ), and up-regulated matrix metalloproteinase (MMP) 9 and MMP2 activity of both trophoblasts and DSCs ( both P < 0.01 ) in an autocrine and paracrine manner
Havre et al., Br J Cancer 2009 (Neoplasm Invasiveness) : This process was regulated in part by the PI-3K and MEK1 pathways, as indicated by increased phosphorylation of p44/42 MAP kinase and Akt in the presence of SDF-1-alpha and the effect of their respective inhibitors on MMP-9 secretion and in vitro invasion
Pandruvada et al., Int J Cancer 2010 (Carcinoma, Squamous Cell...) : Interestingly, CXCL13 treatment to OSCC cells induced CXCR5 and MMP-9 expression suggesting an autocrine regulatory function in OSCC cells
Jovanović et al., Reproduction 2010 : Exogenous IL8/CXCL8 increased trophoblast cell migration and invasion, which may be partly attributable to stimulation of MMP2 and MMP9 levels and an increase in integrins
Stellos et al., Semin Thromb Hemost 2010 (Thrombosis) : The aim of the present study was to evaluate the role of SDF-1 in platelet induced proliferation and differentiation of human CD34 ( + ) cells to macrophages and foam cells, as well as in regulation of matrix metalloproteinase (MMP)-9 secretion
Laird et al., Hum Reprod 2011 : Expression of CXCL12 and CXCR4 in human endometrium ; effects of CXCL12 on MMP production by human endometrial cells ... The aim of this study was to investigate CXCL12 and CXCR4 expression in human endometrium and to see if CXCL12 could affect matrix metalloproteinase ( MMP ) production by endometrial stromal and epithelial cells ... CXCL12 ( 10 and 100 ng/ml ) had no effect on mRNA expression or activity of MMP-2 or MMP-9 in either stromal or epithelial cells ... In contrast to its effects in other cells, CXCL12 had no effect on MMP-2 or MMP-9 production by endometrial stromal or epithelial cells
Uygur et al., Molecular cancer 2011 (Neoplasm Invasiveness...) : We showed that CXCL12 is required for SLUG mediated MMP9 expression in prostate cancer cells
Du et al., Hum Reprod 2012 : CsA up-regulated CXCL12 and CXCR4 expression in human first-trimester cytotrophoblast cells, but not in DSCs. Blocking the mitogen activated proteinkinase/extracellular signal regulated kinase ( MAPK/ERK1/2 ) signaling by U0126 abrogated the CsA induced increase in CXCL12 and CXCR4 expression and neutralizing antibodies to CXCL12 or CXCR4 completely inhibited the CsA induced increase in cell number, invasion and MMP-9 and MMP-2 activity of cytotrophoblast
Kawai et al., Cell Transplant 2012 (Disease Models, Animal...) : At the same time, treatment with MMP-9 enhanced CXCL12 expression, and CXCL12 reciprocally increased MMP-9 expression in BM cells
Pan et al., Mol Biol Rep 2013 (MAP Kinase Signaling System...) : SDF-1a induced MMP-2 and MMP-9 upregulation in PANC-1 and SW-1990 cells, which was associated with increased pancreatic cancer cell proliferation and invasion