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MMP2 — PLG

Text-mined interactions from Literome

Ramos-DeSimone et al., J Biol Chem 1999 (Neoplasm Invasiveness) : When the MMP-9/TIMP ratio exceeds 1.0, MMP-9 activation progresses, but through an interacting protease cascade involving plasmin and stromelysin 1 ( MMP-3 )
Balcerzak et al., J Anim Sci 2001 : The MMP are regulated at the levels of transcription, zymogen activation by plasmin or membrane-type- ( MT ) MMP, and control of enzyme activity by tissue inhibitors of metalloproteinases ( TIMP )
Hosomi et al., Stroke 2001 (Acute Disease...) : Plasminogen activators (PAs) may also play a role in ECM degradation by the generation of plasmin or by MMP activation
Monea et al., J Cell Physiol 2002 : Here, we analyzed the role of MT1-MMP in plasmin activation of MMP-2 using HT-1080 cells transfected with MT1-MMP sense or antisense cDNA ... Thus, plasmin can activate proMMP-2 only in the presence of MT1-MMP ; however, this process does not require the catalytic activity of MT1-MMP
Siconolfi et al., J Neurosci Res 2003 : In this study, we demonstrated, by using tPA and uPA knockout mice, that a lack of a plasminogen activator affected MMP-9 and MMP-2 activity after crushing of the sciatic nerve
May et al., Thromb Haemost 2005 (Arteriosclerosis) : We studied the effect of E-LDL on the activation of plasminogen and matrix metalloproteinases ( MMPs ) in monocytes and vascular smooth muscle cells ( VSMCs ) as well as on MMP activation during cellular interactions
Takano et al., Am J Ophthalmol 2005 : Our results suggested that activation of endogenous MMP-2 by exogenous plasmin is associated with the induction of posterior vitreous detachment
Tan et al., Int J Oncol 2006 (Adenocarcinoma...) : On the other hand, plasmin-treatment induced the expression of matrix metalloproteinase-2 (MMP-2) , MMP-7 and MMP-9 in PC-1 cells
Stempien-Otero et al., J Biol Chem 2006 (Fibrosis) : We hypothesized that : 1 ) macrophage accumulation and cardiac fibrosis in SR-uPA+/o mice are dependent on localization of uPA by the uPA receptor (uPAR) ; 2 ) activation of plasminogen by uPA and subsequent activation of transforming growth factor-beta1 ( TGF-beta1 ) and matrix metalloproteinase (MMP)-2 and -9 by plasmin are critical pathways through which uPA expressing macrophages accumulate in the heart and cause fibrosis ; and 3 ) uPA induced cardiac fibrosis can be attenuated by treatment with verapamil ... We did not detect plasmin mediated activation of TGF-beta1, MMP-2 , or MMP-9 in hearts of SR-uPA+/o mice
Salo et al., Spine (Phila Pa 1976) 2008 (Disease Models, Animal...) : Profiling of various MMPs and plasmin, known to participate in mutual activation cascades, suggests that plasmin could activate pro-MMP-1, pro-MMP-2 , pro-MMP-3, pro-MMP-7, pro-MMP-9, and pro-MMP-13 and alone or/and in cooperation with MMP-3 initiate at least 2 mutual MMPs activation cascades driven by activated MMP-3 and MMP-7
Park et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2010 : Plasminogen activator inhibitor (PAI)-1 is known to play an important role in renal ECM accumulation in part through suppression of plasmin generation and matrix metalloproteinase ( MMP ) activation
Ghosh et al., J Cell Physiol 2012 (Fibrosis) : During wound healing, elevated levels of PAI-1 inhibit uPA/tPA/plasmin and plasmin dependent MMP activities, and, thus, help expedite wound healing
Yamamoto et al., Biochem Biophys Res Commun 2013 (Lung Neoplasms...) : These results suggest that the activation of progalanin by plasmin in the extracellular compartment was involved in MMP-9 and MMP-2 activation and in angiogenesis in tumor tissue
Baramova et al., FEBS Lett 1997 : The pro-MMP-2 activation was inhibited by plasmin inhibitors and anti-uPA antibody
Festuccia et al., Clin Exp Metastasis 1998 (Neoplasm Invasiveness...) : Our results indicate that MMP-9 and MMP-2 are also activated by plasmin generated by cell bound but not by soluble, extracellular uPA