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GNA12 — JUN

Text-mined interactions from Literome

Dermott et al., Oncogene 2004 (Cell Transformation, Neoplastic) : Using this model system, our previous studies have shown that the stimulation of Galpha(12)WT or the expression of an activated mutant of Galpha(12) ( Galpha(12)QL ) leads to increased cell proliferation and subsequent oncogenic transformation of NIH3T3 cells, as well as persistent activation of Jun N-terminal kinases (JNKs)
Collins et al., J Biol Chem 1996 : Transient expression of activated Galpha12 increased the percentage of Ras in the active, GTP bound state, stimulated c-Jun NH2-terminal kinase (JNK) activity, and enhanced the transcriptional activity of c-Jun
Collins et al., Oncogene 1997 (Astrocytoma) : Expression of the SH2 domain of Shc also inhibits G alpha12 mediated induction of an AP-1 dependent reporter gene demonstrating that G12 utilizes Shc to propagate downstream signals