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IRF6 — PTHLH
Text-mined interactions from Literome
Funk et al., Endocrinology 1994
:
IL-4, a prototypical antiinflammatory cytokine, also had a paradoxical effect on
LPS induction of splenic
PTHrP mRNA levels ... Instead of inhibiting
LPS induction of splenic
PTHrP mRNA levels in OuJ or HeJ mice, IL-4 ( 200 ng ) actually stimulated PTHrP mRNA levels
Funk et al., J Clin Invest 1993
:
Since endotoxin ( LPS ) causes many of its effects indirectly by inducing cytokines, studies were undertaken to determine whether
LPS might also
induce splenic
PTHrP expression ... Anti-TNF antibody blocked LPS induction of splenic PTHrP mRNA in C3H/OuJ mice by 68 %, indicating that TNF is a mediator of the
LPS induction of
PTHrP levels