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IRF6 — PKD2

Text-mined interactions from Literome

Song et al., Brain Res 2007 (Myelitis) : Particularly, PKCalpha might be critical for LPS induced PKD activation since the PKCbeta inhibitor ( 100 nM ) observed no effect on the phosphorylation of PKD ... These results demonstrated for the first time that PKD could be activated by LPS in spinal neurons, might via the IL-1beta/PKCalpha pathway
Duan et al., Inflamm Res 2011 (Drug-Induced Liver Injury...) : The results indicated that LPS/D : -GalN administration markedly induced hepatic PKD activation, lethality and liver injury, while pretreatment of the PKD inhibitor Gö6976 significantly inhibited LPS induced PKD activation, improved the survival of LPS/D : -GalN administered mice and attenuated LPS/D : -GalN induced liver injury, as evidenced by reduced levels of serum aminotransferases as well as reduced histopathological changes