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CD40 — IRF6

Text-mined interactions from Literome

Li et al., Scand J Immunol 2000 : Lipopolysaccharide (LPS) treatment induced the upregulation of CD40 , CD80, CD86 and the T-cell stimulatory capacity in IL-4-DCs and, to a lesser extent, in the IL-7-DCs whereas GM-CSF-DCs responded very poorly to such treatment
Berthier et al., J Immunol Methods 2000 : The splenic DC produced after 2 weeks of culture are fully functional, exhibiting a high capacity of endocytosis when immature, a strong stimulatory reactivity in mixed leukocyte reaction and consistently producing high levels of bioactive IL-12 p70 after CD 40 ligation in the presence of LPS between 13 and 43 days of culture
Arrighi et al., J Immunol 2001 (Dermatitis, Allergic Contact) : SB203580, an inhibitor of the p38 MAPK, but not the extracellular signal regulated kinase l/2 pathway blocker PD98059, inhibited the up-regulation of CD1a, CD40 , CD80, CD86, HLA-DR, and the DC maturation marker CD83 induced by LPS and TNF-alpha
Bone et al., Int Immunol 2001 : Nuclear NF-kappaB is induced in B cells by engagement of either the BCR or CD40 or by stimulation with lipopolysaccharide (LPS)
Seixas et al., Eur J Immunol 2001 : In contrast to some strains of the human parasite, P. falciparum, P.c. chabaudi ( AS ) did not inhibit the up-regulation of MHC class II, CD86 or CD40 induced by LPS
Kim et al., J Neuroimmunol 2002 : The inclusion of an anti-IL-10 antibody completely abrogated PACAP inhibition of lipopolysaccharide (LPS) induced CD40 expression, suggesting that PACAP inhibition is at least in part mediated by IL-10
Zhao et al., J Immunol 2003 (Inflammation) : Importantly, LPS induced gene expression of CD40 and Act1 in the mouse lung is abolished in IRF-1 ( -/- ) mice, indicating an essential role of transcription factor IRF-1 in the coordinated regulation of these two genes during airway inflammation
Weigt et al., Immunobiology 2003 : MALP-2 and LPS stimulation induced the expression of CD83 and increased the expressions of CD80, CD86, HLA-ABC and CD40
Yamada et al., Eur J Immunol 2004 : In contrast, C1q failed to suppress colony formation of B cells responding to LPS or LPS induced CD40 and CD86 expression on BMDC in MyD88-deficient mice, indicating that inhibitory effects of C1q on MyD88 independent pathways may be limited
Mahanonda et al., J Dent Res 2004 (Periodontitis) : LPS stimulation resulted in a dose dependent up-regulation of CD40 , CD80, and CD86 on monocytes, and up-regulation of CD69 on NK cells and gamma delta T-cells in both the periodontitis and non-periodontitis groups
Chen et al., J Immunol 2004 : PS liposomes inhibited the up-regulation of HLA-ABC, HLA-DR, CD80, CD86, CD40 , and CD83, as well as the production of IL-12p70 by human DCs in response to LPS
Drohan et al., Hum Immunol 2004 : APB monocytes also showed a greater LPS induced increase in CD40 expression
Dimayuga et al., J Neuroimmunol 2005 (Encephalitis) : Specifically, the effects of 17beta-estradiol on basal and LPS induced surface staining of Class I and II MHC, as well as CD40 , CD80, CD86, CD152, CD28, CD8, CD11b, Fas, FasL, and also ERalpha and ERbeta, were examined in N9 microglial cells
Aki et al., Genes Cells 2005 : Unexpectedly, LPS induced CD40 activation and the secretion of pro-inflammatory cytokine such as IL-6 and TNF-alpha, was down-regulated in Csk knockdown cells
Norata et al., J Intern Med 2005 (Carotid Stenosis) : Furthermore, we investigated whether monocyte from D299G to T399I subjects present a defective response to CD40 , interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, cyclo-oxygenase (COX)-2 and PTX3 expression induced by lipopolysaccharide (LPS)
Qin et al., Blood 2005 : LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia ... In this study, we describe that LPS is a strong inducer of CD40 expression in macrophages and microglia, which occurs at the transcriptional level and involves the activation of the transcription factors nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription 1alpha ( STAT-1alpha ) ... LPS induced CD40 expression involves the endogenous production of the cytokine interferon-beta (IFN-beta), which contributes to CD40 expression by the activation of STAT-1alpha ... Blocking IFN-beta induced activation of STAT-1alpha by IFN-beta neutralizing antibody reduces LPS induced CD40 gene expression ... These results indicate that both LPS induced NF-kappaB activation and endogenous production of IFN-beta that subsequently induces STAT-1alpha activation play critical roles in the transcriptional activation of the CD40 gene by LPS
Vassallo et al., J Immunol 2005 : Conditioning of DCs with CSE also suppressed LPS mediated induction of CD40 , CD80, and CD86, and suppressed maturation associated CCR7 expression
Vowinkel et al., Am J Physiol Heart Circ Physiol 2006 : Constitutive expression of CD40 was profoundly reduced in unstimulated CD40L-/- mice, but the LPS induced CD40 upregulation did not differ between CD40L-/- and WT mice
Takaki et al., Genes Cells 2006 : Although TGF-beta1 did not greatly affect the activation of APCs, as assessed by the induction of IL-12 or the upregulation of CD40 in response to LPS , it strongly inhibited IFN-gamma induced nitric oxide ( NO ) production from macrophages and dendritic cells
Curran et al., Cell Immunol 2006 : Both bLF and LPS stimulated IL-6 production and CD40 expression in RAW 264.7 macrophages and in BALB/cJ peritoneal exudate macrophages
Qin et al., J Immunol 2006 : In this study, we discovered that IL-10, a cytokine with anti-inflammatory properties, inhibits LPS induced CD40 gene expression ... We previously demonstrated that LPS induction of CD40 in macrophages/microglia involves both NF-kappaB activation and LPS induced production of IFN-beta, which subsequently activates STAT-1alpha ... Ectopic expression of SOCS-3 attenuates LPS induced STAT activation, and inhibits LPS induced CD40 gene expression, comparable to that seen by IL-10 ... These results indicate that SOCS-3 plays an important role in the negative regulation of LPS induced CD40 gene expression by IL-10
Zhang et al., Am J Nephrol 2006 : This study was to investigate the expression of PPARgamma in rat PMCs and the effect of PPARgamma activation on the production of CD40 and ICAM-1 induced by lipopolysaccharide (LPS) ... There is constitutive expression of PPARgamma in cultured RPMCs and PPARgamma ligands which strongly inhibit LPS induced CD40 and ICAM-1 production in RPMCs
Zhou et al., J Immunol 2007 : Iloprost and cicaprost also suppressed LPS induced expression of CD86, CD40 , and MHC class II molecules by BMDCs and inhibited the ability of BMDCs to stimulate Ag-specific CD4 T cell proliferation and production of IL-5 and IL-13
Mahanonda et al., Asian Pac J Allergy Immunol 2006 : Unlike Escherichia coli and A. actinomycetemcomitans LPS, P. gingivalis LPS induced only low levels of CD40 , CD80, HLA-DR and CD83 expression on Mo-DCs
Sá-Nunes et al., J Immunol 2007 : Moreover, we have found that I. scapularis saliva ( dilution 1/200 ; approximately 10 nM PGE ( 2 ) ) marginally inhibited LPS induced CD40 , but not CD80, CD86, or MHC class II expression
Jiang et al., J Immunol 2007 : NGF could markedly promote LPS induced expression of HLA-DR, CD40 , CD80, CD83, CD86, CCR7, secretion of IL-12p40 and proinflammatory cytokines IL-1, IL-6, TNF-alpha, and the T cell stimulating capacity of MoDCs, indicating that NGF can promote LPS induced DC maturation
Wu et al., Toxicol Appl Pharmacol 2008 : Involvement of mitogen activated protein kinases and NFkappaB in LPS induced CD40 expression on human monocytic cells ... The mechanisms regulating lipopolysaccharide (LPS) induced CD40 expression have not been adequately characterized in human monocytic cells ... Further studies using immunoblotting and pharmacological inhibitors revealed that mitogen activated protein kinases ( MAPKs ) and NFkappaB were activated by LPS exposure and involved in LPS induced CD40 expression ... In summary, LPS induced CD40 expression in monocytic cells involves MAPKs and NFkappaB
Xu et al., Immunology 2008 : Following LPS stimulation, up-regulation of the surface markers CD40 , CD86, I-Ad, immunoglobulin M, CD54 and interleukin-10 production, accompanied by down-regulation of CD5 and CD184 ( CXCR4 ) were observed in a LPS dose dependent manner
Lee et al., J Korean Med Sci 2008 : On the other hand, porcine SCs and their culture supernatant suppressed the up-regulation of CD40 expression ( p < 0.05 ) on DCs in the presence of LPS stimulation
Lu et al., Int Immunopharmacol 2008 : In the presence of LPS , VIP also dose dependently up-regulated the expression of CD80, CD86, CD54 and CD40 , and down-regulated the expression of Ia ( b )
Wu et al., Biochem Biophys Res Commun 2009 : Mechanisms of LPS induced CD40 expression in human peripheral blood monocytic cells ... In this study, we explored mechanisms underlying lipopolysaccharide (LPS) induced CD40 expression in purified human peripheral blood monocytic cells ( PBMCs ) from healthy volunteers ... Inhibition of NFkappaB activation abrogated LPS induced CD40 expression ... LPS stimulation also resulted in phosphorylation of mitogen activated protein kinases, however, only Jun N-terminal kinase (JNK) was partially involved in LPS induced CD40 expression ... In addition, LPS exposure resulted in elevated interferon gamma (IFNgamma) levels in the medium of PBMCs. Neutralization of IFNgamma and IFNgamma receptor using specific antibodies blocked LPS induced CD40 expression by 44 % and 37 %, respectively ... In summary, LPS induced CD40 expression on human PBMCs through activation of NFkappaB and JNK, and partially through the induction of IFNgamma production
Yanaba et al., J Immunol 2009 : Prolonged LPS or CD40 stimulation of newborn spleen and adult blood or lymph node CD1d ( low ) and/or CD5 ( - ) B cells also induced cytoplasmic IL-10 competence in rare B cells, with CD40 ligation uniformly inducing CD5 expression
Dohnal et al., J Cell Mol Med 2009 : Accordingly, we demonstrated that CD40/CD40L but not TLR4 or TLR3 signalling mediated by LPS or poly ( cytidylic-inosinic ) acid ( poly I:C ) and dsRNA re-established the capacity for secreting interleukin (IL)-12 in primarily LPS/IFN-gamma activated DCs, which have exhausted their potential for cytokine secretion
Touma et al., J Immunol 2011 : B cells from I?BNS knockout ( KO ) mice were impaired in proliferative responses to LPS and anti-CD40
Qureshi et al., Lipids in health and disease 2011 (Inflammation...) : The microarray DNA analyses, followed by pathway analyses indicated that quercetin or d-tocotrienol inhibit several LPS induced expression of several ageing and pro-inflammatory genes ( IL-1ß, IL-1a, IL-6, TNF-a, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40 )
Benson et al., J Diet Suppl 2010 (Inflammation) : BRC-301 decreased the LPS induced production of nitric oxide and IL-6, as well as CD40 expression
Kim et al., Food Chem Toxicol 2013 (Inflammation) : Furthermore, DPEP inhibited the LPS induced phosphorylation of inhibitor ?B ( I?B ) -a and NF-?B p50
Fu et al., PloS one 2013 (Inflammation) : The expression of LPS induced major histocompatibility complex class II, CD40 , and CD86 on DCs was also decreased by acetylcorynoline, and the endocytic capacity of LPS stimulated DCs was restored by acetylcorynoline
Gasparotto et al., Cell Biol Toxicol 2013 : Besides, STP significantly inhibited LPS induced TNF-a and IL-1ß release, as well as CD40 and TNF-a protein upregulation
Kone et al., Am J Physiol 1995 : LPS + interferon-gamma (IF-gamma) promoted a time dependent increase in nitrite ( a NO metabolite ) and iNOS mRNA and the appearance of NF-kappa B p50 and p65 in nuclear protein extracts
Jakob et al., J Immunol 1998 : Flow cytometry of FSDDC-A revealed that IL-1, TNF-alpha, and LPS induced increased expression of MHC class II, CD40 , and CD86 and decreased E-cadherin expression that was temporally related to dissociation of aggregates