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ABCC1 — IRF6

Text-mined interactions from Literome

Sunohara et al., J Neurochem 2001 : Pro-inflammatory cytokines produced by activated microglia ( IL-1beta, IL-6, TNF-alpha ) did not mimic LPS effects on MARCKS or MRP expression when added individually or in combination ... Induction of MARCKS and MRP by LPS was completely blocked by inhibitors of NF-kappaB ( PDTC ) and protein tyrosine kinases ( herbimycin A ), partially blocked by the p38 kinase inhibitor SB203580, and unaffected by the MEK inhibitor PD98059 ... The Src kinase inhibitor PP2 had no effect, while the closely related inhibitor PP1 actually increased LPS induction of MARCKS and MRP
Donner et al., Biol Chem 2004 : Therefore, the effect of LPS on the zonal localization of Mrp2 and Mrp3 and the expression of Mrp3 , Mrp4, Mrp5, and Mrp6 mRNA were investigated in rat liver ... It is concluded that Mrp3 is inversely regulated to Mrp2 in a zonal pattern and may compensate for the LPS induced loss of Mrp2 in the perivenous area
Cherrington et al., Drug Metab Dispos 2004 : In contrast, LPS increased mRNA levels of Mrp1, Mrp3 , and Mdr1b concurrently with the down-regulated transporters ... Furthermore, dexamethasone pretreatment also prevented the LPS mediated increase in Mrp1, Mrp3 , and Mdr1b, whereas pretreatment with aminoguanidine or gadolinium chloride, an inhibitor of inducible nitric oxide synthetase and a Kupffer cell toxicant, respectively, had no effect on the LPS induced changes
Siewert et al., Biochem Biophys Res Commun 2004 (Acute-Phase Reaction) : In IL-6-deficient mice, turpentine failed to decrease mRNA-levels of basolateral and canalicular transporters, whereas LPS mediated down-regulation of Ntcp, Mrp3 , and Mrp2 was abolished at later time points ( 24 h )
Kido et al., J Periodontol 2005 : P-LPS increased MRP14 mRNA expression in monocytes to the maximum level, about two times the control level after 24 hours treatment, but did not enhance the basal level of MRP8
Yano et al., Biochem Pharmacol 2010 : The effect of dimerumic acid on LPS induced downregulation of Mrp2 in the rat
Gibson et al., J Pharmacol Exp Ther 2012 (Inflammation) : Conversely, LPS increased expression of Mrp1 and Mrp5 mRNA and protein
Schymeinsky et al., PloS one 2013 (Asthma...) : Similarly, LPS induced TNFa release in murine whole blood of Mrp4 ( +/+ ) or Mrp4 ( -/- ) mice was not reduced by KO143 ( 1, 10 µM )
Rosé et al., J Neurosci Res 1996 : Within 6 hours of addition, LPS induced a twofold increase in [ 3H ] myristoylated and immunoreactive MARCKS protein and a sevenfold increase in MRP ... The differential effect of LPS on expression of MRP vs. MARCKS was even more dramatic at the level of transcription : S1 nuclease protection assays revealed a 40-fold increase in MRP mRNA levels ( maximum at 4-6 hours ), whereas a threefold increase was observed for MARCKS ... TNF alpha and colony stimulating factor 1 (CSF-1), two cytokines which are induced by LPS, did not reproduce the observed effect of LPS on MARCKS and MRP gene transcription
Kubitz et al., Gastroenterology 1999 : LPS induced the appearance of MRP2 in intracellular vesicles in the immediate vicinity of the canaliculi within 3 hours, and these vesicles were remote from the canaliculi after 6 and 12 hours ... Dexamethasone counteracted the LPS effects on MRP2 mRNA levels, subcellular distribution, and BSP excretion