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ANGPT2 — IL6

Text-mined interactions from Literome

Funakoshi et al., Hypertension 1999 : In this report, we investigated the effect of Ang II on the production of interleukin-6 (IL-6) , which is a multifunctional proinflammatory cytokine in rat vascular smooth muscle cells
Sano et al., Circ Res 2001 : Collectively, these data indicated that Ang II stimulated ROS production via the AT1 receptor and NADH/NADPH oxidase, and that these ROS mediated activation of MAPKs, which culminated in IL-6 gene expression through a CRE dependent, but not NF-kappaB dependent, pathway in cardiac fibroblasts
Penkowa et al., J Neurosci Res 2003 (Disease Models, Animal...) : Also, IL-6 induced significant increases in proinflammatory cytokines IL-1, IL-12, and tumor necrosis factor-alpha as well as growth factors basic fibroblast growth factor (bFGF), transforming growth factor-beta, neurotrophin-3, angiopoietin , vascular endothelial growth factor, and the receptor for bFGF
Skurk et al., Arterioscler Thromb Vasc Biol 2004 (Inflammation) : Ang II stimulates IL-6 and IL-8 production and release from human adipocytes by a NF-kappaB dependent pathway
Cui et al., Circ Res 2006 : In vascular smooth muscle cells ( VSMCs ), Ang II signaling activates interleukin (IL)-6 expression, a cytokine producing acute-phase inflammation, mediated by the transcription factor nuclear factor kappaB (NF-kappaB)
Vart et al., Cancer Res 2007 (MAP Kinase Signaling System...) : Kaposi 's sarcoma associated herpesvirus encoded interleukin-6 and G-protein coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells
Choudhary et al., Mol Endocrinol 2007 : Finally, we demonstrate that Ang II infusion in vivo rapidly induces phospho-Ser ( 536 ) RelA formation and activation of the NF-kappaB dependent IL-6 gene
Kandalam et al., Regul Pept 2010 : In this study, we investigated whether Ang II induces Janus kinase (JAK) 2, signal transducer and activators of transcription ( STAT ) 3 phosphorylation, and interleukin-6 (IL-6) secretion in cultured brainstem rat astrocytes ... Our study showed for the first time that Ang II induced JAK2/STAT3 phosphorylation and IL-6 secretion through activation of the Ang II AT(1) receptor in brainstem astrocytes
Peng et al., Life Sci 2010 : The results showed that both IL-6 and Ang II increased CRP levels in the supernatant of VSMCs and induced mRNA and protein expression of CRP in VSMCs, whereas pretreatment of the cells with EGCG ( 1 x 10 ( -6 ) M, 3 x 10 ( -6 ) M, 10 x 10 ( -6 ) M ) significantly inhibited IL-6- and Ang II-induced production and expression of CRP in VSMCs in a concentration dependent manner
Zack et al., Atherosclerosis 2011 (Aortic Aneurysm, Abdominal...) : Ang II induction of cyclooxygenase-2, interleukin-6 , matrix metalloproteinase (MMP)-2, MMP-13 and MMP-14 was reduced significantly in GX DKO mice compared to apoE ( -/- ) mice
Guo et al., J Interferon Cytokine Res 2011 : Ang II not only induced the production of tumor necrosis factor-a, IL-1ß, IL-6 , and IL-10 but also increased the release of ROS
Mofarrahi et al., PloS one 2011 : In human myoblasts, ANGPT2 expression was induced by H ( 2 ) O ( 2 ), but not by TNFa, IL1ß or IL6 ... In human myoblasts, ANGPT2 expression was induced by H ( 2 ) O ( 2 ), but not by TNFa, IL1ß or IL6
Beasley et al., J Cardiovasc Pharmacol 1997 : In contrast, IL-1 and Ang II activate IL-6 gene expression by a pathway distinct from that of phorbol ester-responsive PKC