Gene interactions and pathways from curated databases and text-mining

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IL12B — VEGFA

Text-mined interactions from Literome

Matsumoto et al., Nephron 2000 (Nephrosis, Lipoid) : Taken together, our results indicate that both IL-18 and IL-12 contribute to the VPF production in vitro and suggest that they play key roles in the complexity of cytokine regulation in the pathophysiology of VPF
Nakayama et al., Anticancer Res 2000 (Colorectal Neoplasms) : IL-12 may regulate VEGF in the patients diagnosed with colorectal cancer
Kang et al., Leukemia & lymphoma 2006 (Leukemia) : Inhibition of cellular VEGF levels increased interleukin (IL)-12 production and the allostimulatory capacity of leukemic DCs
Block et al., Clin Cancer Res 2011 (Mammary Neoplasms, Experimental...) : Human but not mouse APCs upregulate VEGFR2 and downregulate interleukin (IL)-12ß in response to VEGF
Ferrante et al., Inflammation 2013 : Adenosine signaling suppresses the TLR dependent expression of TNF-a, IL-12 , IFN-?, and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10
Burnham et al., Am J Physiol Lung Cell Mol Physiol 2013 (Alcoholism) : Cigarette smoking duration was associated with higher IL-1ß ( P = 0.0009 ) but lower VEGF ( P = 0.0007 ) ; cigarette smoking intensity was characterized by higher IL-1ß and lower VEGF and diminished IL-12 ( P = 0.0004 )
Matsumoto et al., Nephron 1998 (Glomerulonephritis, IGA...) : We, therefore, investigated the effects of recombinant human IL-12 on the release of VPF by peripheral blood mononuclear cells ( PBMC ) from LN patients ... Recombinant human IL-12 was found to enhance VPF release in a dose dependent manner
Dias et al., Int J Cancer 1998 (Mammary Neoplasms, Experimental...) : IL-12 regulates VEGF and MMPs in a murine breast cancer model