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IL12B — IL21

Text-mined interactions from Literome

Strengell et al., J Immunol 2003 : We have previously shown that IL-15 and IL-21 induce the expression of IFN-gamma, T-bet, IL-12R beta 2, and IL-18R genes both in NK and T cells
Strengell et al., J Leukoc Biol 2004 : We demonstrate here that in addition to activating IFN-gamma gene expression, IFN-alpha/beta and IL-12 enhance the mRNA expression of IL-21 in activated human T cells
Monteleone et al., Gastroenterology 2005 (Colitis, Ulcerative...) : We also examined the effects of exogenous IL-12 on IL-21 production, as well as the effects of blocking IL-21 with an IL-21-receptor Ig fusion protein ... IL-12 enhanced IL-21 in normal lamina propria lymphocytes through an IFN-gamma independent mechanism, and blocking IL-12 in CD LPMCs decreased anti-CD3 stimulated IL-21 expression
Casey et al., J Immunol 2007 : Furthermore, IL-21 fails to induce IFN-gamma or IL-4 production and can partially block IL-12 induction of IFN-gamma production
Schmitt et al., Immunity 2009 : IL-12 induced two different IL-21-producers : IL-21 ( + ) IFN-gamma ( + ) T-bet ( + ) Th1 cells and IL-21 ( + ) IFN-gamma ( - ) T-bet ( - ) non-Th1 cells, in a manner dependent on signal transducer and activator of transcription 4 ( STAT4 ) ... IL-12 also regulated IL-21 secretion by memory CD4 ( + ) T cells
Sutton et al., Immunity 2009 (Encephalomyelitis, Autoimmune, Experimental) : Here, we show that gammadelta T cells express IL-23R and the transcription factor RORgammat and produce IL-17, IL-21 , and IL-22 in response to IL-1beta and IL-23 , without T cell receptor engagement
Mus et al., Arthritis Rheum 2010 (Arthritis, Experimental) : IL-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of IL-22, but not IL-21 , levels in autoimmune arthritis
Sarra et al., Inflamm Bowel Dis 2010 (Inflammatory Bowel Diseases) : To assess the involvement of IL-12 and IL-23 in the production of IL-21 , T-LPL were activated in the presence or absence of IL-12 or IL-23 ... To assess the involvement of IL-12 and IL-23 in the production of IL-21 , T-LPL were activated in the presence or absence of IL-12 or IL-23
Ma et al., Blood 2012 : Although STAT1 was dispensable, mutations in IL12RB1, TYK2, or STAT3 compromised IL-12 induced expression of IL-21 by human CD4 ( + ) T cells
Hegde et al., Cell Immunol 1995 (Neoplasms, Experimental) : AK-5 tumor induced expression of interleukin-12 : role of IL-12 in NK-mediated AK-5 regression