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CD28 — IL10

Text-mined interactions from Literome

Koprak et al., Cell Immunol 1999 : A specific inhibitor of the p38 mitogen activated protein kinase affects differentially the production of various cytokines by activated human T cells : dependence on CD28 signaling and preferential inhibition of IL-10 production
Van Gool et al., Eur J Immunol 1999 : Blocking CD40 - CD154 and CD80/CD86 - CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production
Okkenhaug et al., Nat Immunol 2001 : Nonetheless, this mutated form of CD28 still prevents the induction of anergy and promotes T cell proliferation, interleukin 2 secretion and B cell help
Akdis et al., Int Arch Allergy Immunol 2001 (Hypersensitivity) : Accordingly, IL-10 binding to its receptor inhibits CD28 tyrosine phosphorylation, the initial step of the CD28 signaling pathway
Akdis et al., Immunology 2001 (Hypersensitivity) : IL-10 inhibits CD28 tyrosine phosphorylation, the initial step of the CD28 signalling pathway, and consequently the phosphatidylinositol 3-kinase p85 binding to CD28
Janssen et al., Am J Respir Cell Mol Biol 2002 (Asthma...) : This IL-10 production by the OVA-Mphi was dependent on MHC-TCR and CD86-CD28, but not CD80-CD28 or CD40-CD154 interactions
Witsch et al., Eur J Immunol 2002 : ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells
Aspalter et al., J Leukoc Biol 2003 : In addition, cross linking TNF-RII had the capacity to down-regulate TCR/CD28 induced Ca++ mobilization, IL-2 mRNA expression, and IL-2 and IL-10 secretion
Yamana et al., Arthritis Res Ther 2004 (Arthritis, Rheumatoid) : We found that peripheral blood CD4+ T cells from patients with active rheumatoid arthritis ( RA ) were able to produce greater amounts of interferon gamma after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 than were normal control CD4+ T cells, although their surface expression of the type 1 IL-10 receptor was increased
Veras et al., Exp Parasitol 2006 (Leishmaniasis, Cutaneous) : Interestingly, IL-10- producing B cells were reduced in response to anti-CD3/anti-CD28 stimulation combined with L. major compared to the other groups
Taylor et al., Immunology 2006 : IL-10 inhibits CD28 tyrosine phosphorylation, preventing the binding of phosphatidylinositol 3-kinase p85 and consequently inhibiting the CD28 signalling pathway
Kim et al., J Immunol 2009 : CD28 mediated costimulation dramatically enhanced T cell IL-10 production, yet neither ICOS nor CD86 was involved in IL-10 production
Abreu et al., Arthritis Res Ther 2010 (Arthritis, Experimental...) : Ex vivo, Rac1 inhibitory peptide suppressed T-cell receptor/CD28 dependent production of tumor necrosis factor alpha, interferon gamma and interleukin-17 by T cells from collagen primed mice, and reduced induction of ICOS and CD154, T-cell costimulatory proteins important for B-cell help
Milliken et al., J Allergy Clin Immunol 2012 : UV treatment was also followed by reduced proliferative and IL-10 responses to anti-CD3/CD28 independent of the 25 ( OH ) D level
Dobber et al., Cell Immunol 1995 : This was not due to lack of CD28 triggering since anti-CD28 enhanced IFN-gamma as well as IL-4 and IL-10 to a similar extent
de Waal Malefyt et al., J Immunol 1993 : IL-10 did not affect the expression of the TCR/CD3 complex, CD2, LFA-1, CD28 , or IL-2R alpha- or beta-chains, nor did it inhibit the induction of the latter two molecules on T cells after activation
Schwarz et al., Immunology 1995 : Similar to the other cytokines, in peripheral blood mononuclear cells ( PBMC ) from adult donors the highest IL-10 levels were produced in response to CD2 plus CD28 stimulation, within 72-96 hr of stimulation ... Levels of IL-10 in response to CD2 plus CD28 stimulation ( 1.9 +/- 1 ng/ml ) exceeded those in response to SEA ( 0.25 +/- 0.16 ng/ml ), SAC ( 0.43 +/- 0.42 ng/ml ), or LPS ( 0.19 +/- 0.14 ng/ml ) stimulation
Wang et al., J Immunol 1997 (Shock, Septic) : Thus, we conclude that ligation of CD28 induces expression of IL-10 , which in turn suppresses TNF-alpha production and prevents septic shock
Dumont et al., J Immunol 1998 : FK506 also reduced CD3/CD28 induced production of IL-3, IL-4, IL-10 , TNF-alpha, and IL-6 but augmented that of GM-CSF, IL-5, IFN-gamma, and IL-13