Kaaks et al., Gynecol Obstet Fertil 2001
(Breast Neoplasms) :
Like insulin, IGF-I also inhibits the hepatic synthesis of SHBG , whereas both hormones stimulate the ovarian synthesis of sex steroids
Kalme et al., J Steroid Biochem Mol Biol 2003
:
IGF-I and IGF-II also inhibited the IGFBP-1 and SHBG levels
McCarty et al., Med Hypotheses 1997
(Arteriosclerosis...) :
Since IGF-1 suppresses hepatic synthesis of sex hormone binding globulin (SHBG), down-regulation of IGF activity will increase SHBG levels and thus diminish the availability of free sex hormones -- an effect that should further decrease cancer risk in sex hormone-responsive tissues