Wang et al., Genes Immun 2011
:
Let-7/miR-98 regulate Fas and Fas mediated apoptosis ... Indeed ectopic expression of let-7/miR-98 reduced , whereas knockdown of endogenous let-7/miR-98 increased the expression of Fas at both mRNA and protein levels
Lin et al., Invest Ophthalmol Vis Sci 2011
(Macular Degeneration) :
Forced overexpression of miR-23a decreased H ( 2 ) O ( 2 ) or tBH induced Fas upregulation, and this effect was blocked by downregulation of miR-23a Huang et al., Cancer Res 2012
(Bone Neoplasms...) :
Overexpression of miR-20a consistently resulted in the downregulation of Fas expression in SAOS-2 cells and thus in decreased sensitivity to FasL
Wang et al., Mol Carcinog 2013
(Stomach Neoplasms) :
miR-106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS Guo et al., Blood 2013
(Autoimmune Lymphoproliferative Syndrome) :
These results indicate that miR-146a may be involved in the pathogenesis of ALPS by targeting Fas and may therefore serve as a novel therapeutic target