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BTC — ERBB3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of EGFR-ERBB3 → BTC (directlyIncreases)
  Evidence: the second group betacellulin (BTC), heparin-binding EGF (HB-EGF), and epiregulin (EPR), which exhibit dual specificity in that they bind ErbB1 and ErbB4.
• OpenBEL Selventa BEL large corpus: Complex of ERBB3-PIK3R1 → BTC (increases) Daly et al., Oncogene 1999*
  Evidence: Treatment of cells with BTC increased the association of p85 subunit of PI3K with ErbB3.
• OpenBEL Selventa BEL large corpus: ERBB3 → BTC (increases) Shin et al., Circ Res 2003*
  Evidence: BTC induced phosphorylation of all four EGF receptors present on HTASMCs: ErbB1, ErbB2, ErbB3, and ErbB4.
• OpenBEL Selventa BEL large corpus: ERBB3 → BTC (increases) Daly et al., Oncogene 1999*
  Evidence: NDF and Betacellulin (BTC) induced increase in tyrosine phosphorylation of ErbB3. NDF induced the strongest increase in the ErbB3 phosphotyrosine.
• Reactome Reaction: BTC → ERBB3 (indirect_complex) Riese et al., Mol Cell Biol 1995
• Reactome Reaction: BTC → ERBB3 (reaction) Vijapurkar et al., Exp Cell Res 2003, Walton et al., J Biol Chem 1990, Li et al., Cell Signal 2007, Xu et al., Mol Cell Biol 2007, Hazan et al., Cell Growth Differ 1990, Kaushansky et al., Chem Biol 2008, Helin et al., J Biol Chem 1991, Margolis et al., J Biol Chem 1989, Ricci et al., Oncogene 1995, Wallasch et al., EMBO J 1995, Riese et al., Mol Cell Biol 1995, Prigent et al., EMBO J 1994, Soler et al., Oncogene 1994, Segatto et al., Oncogene 1993, Cohen et al., J Biol Chem 1996, Pinkas-Kramarski et al., EMBO J 1996

Text-mined interactions from Literome

Beerli et al., J Biol Chem 1996 (Breast Neoplasms) : Consequently, only NDF, HB-EGF, and BTC significantly stimulated association of phosphatidylinositol kinase activity with ErbB-3
Graus-Porta et al., EMBO J 1997 (Vulvar Neoplasms) : Furthermore, EGF- and BTC induced activation of ErbB-3 is impaired in the absence of ErbB-2, suggesting that ErbB-2 has a role in the lateral transmission of signals between other ErbB receptors