◀ Back to EGFR

EGFR — HDAC6

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EGFR — HDAC6 (colocalization, biochemical) Gao et al., J Biol Chem 2010*
• IRef Biogrid Interaction: EGFR — HDAC6 (physical association, affinity chromatography technology) Gao et al., J Biol Chem 2010*
• IRef Intact Interaction: EGFR — HDAC6 (physical association, ubiquitin reconstruction) Deribe et al., Science signaling 2009
• IRef Intact Interaction: EGFR — HDAC6 (phosphorylation reaction, protein kinase assay) Deribe et al., Science signaling 2009
• IRef Intact Interaction: EGFR — HDAC6 (physical association, anti tag coimmunoprecipitation) Deribe et al., Science signaling 2009
• IRef Intact Interaction: EGFR — HDAC6 (physical association, anti bait coimmunoprecipitation) Deribe et al., Science signaling 2009
• IRef Intact Interaction: Complex of HSPA1A-HDAC6-AP2A1-EGFR-MAP3K12 (association, anti bait coimmunoprecipitation) Deribe et al., Science signaling 2009

Text-mined interactions from Literome

Kim et al., Radiother Oncol 2009 (Neoplasms) : Conversely, ectopic overexpression of HDAC6 isotype increased the levels of p-EGFR and p-AKT expression, and reduced LBH589 mediated radiosensitization
Gao et al., J Biol Chem 2010 : The microtubule associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation ... We found that loss of HDAC6 promoted EGFR degradation
Liu et al., PloS one 2012 : We present for the first time that histone deacetylase 6 (HDAC6) regulates EGFR degradation and trafficking along microtubules in Pkd1 mutant renal epithelial cells
Arsenault et al., PloS one 2013 (Anoxia...) : Our data provide evidence that hypoxia influences invadopodia formation in a biphasic manner, which involves the activation of HDAC6 deacetylase activity by EGFR , resulting in enhanced Smad phosphorylation and nuclear accumulation