Nunes et al., Mol Cancer Ther 2004
:
To understand the latter phenomenon, the effect of EKB-569 on EGF-R as well as downstream signaling to phosphoinositide 3-kinase-protein kinase B ( AKT ), extracellular signal regulated kinase 1 and 2 ( ERK1/2 ), or signal transducer and activator of transcription 3 ( STAT3 ) pathways were compared in tumor cell lines and normal human keratinocytes ( NHEK ) grown in tissue culture
Erlichman et al., J Clin Oncol 2006
(Neoplasms) :
Phase I study of EKB-569 , an irreversible inhibitor of the epidermal growth factor receptor , in patients with advanced solid tumors
Folprecht et al., Clin Cancer Res 2008
(Colorectal Neoplasms) :
At the RD, EKB-569 resulted in complete inhibition of phosphorylated EGFR ( pEGFR ) and downstream receptor signaling in skin and tumor samples