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ADAM10 — EGFR
Text-mined interactions from Literome
Schäfer et al., Oncogene 2004
(Neoplasm Invasiveness...) :
Moreover, we report that the
EGFR transactivation signal
involves the EGFR ligands amphiregulin, HB-EGF and TGFalpha as well as the metalloproteinases
ADAM 10 , 15 and 17, depending on the cellular system
Tanida et al., Gastroenterology 2004
(Stomach Neoplasms) :
Although this
EGFR transactivation reportedly
requires a disintegrin and metalloproteinase (
ADAM ) that sheds the ectodomain of EGFR ligands, the detailed mechanisms are still unknown ... Depletion of
ADAM10 also dramatically
reduced IL-8 induced shedding and
EGFR transactivation, but depletion of ADAM12 and 17 did not
Itoh et al., Cytokine 2005
(Carcinoma...) :
IL-8 transiently induced
EGFR tyrosine phosphorylation after 5-90 min and this was completely
inhibited by
ADAM inhibitor
Joh et al., Dig Dis Sci 2005
:
Helicobacter pylori stimulated interleukin-8 (IL-8) promotes cell proliferation through transactivation of
epidermal growth factor receptor (EGFR) by disintegrin and metalloproteinase (
ADAM )
activation
Ohtsu et al., Am J Physiol Cell Physiol 2006
:
The major focus of the review will be on the possible upstream mechanisms of ADAM activation by GPCRs as well as downstream signal transduction and the pathophysiological significances of
ADAM dependent
EGFR transactivation
Bech-Serra et al., Mol Cell Biol 2006
(Neoplasms) :
Activation of the
epidermal growth factor receptor leads to the upregulation of the shedding of Dsg-2 and to the concomitant upregulation of ADAM17, but not
ADAM10 , supporting the ability of overexpressed ADAM17 to shed Dsg-2
Yin et al., Invest Ophthalmol Vis Sci 2009
:
Wounding-, LPA-, and ATP induced HB-EGF shedding and
EGFR activation were
attenuated by the MAPK/ERK kinase (MEK) inhibitors PD98059 and U0126, as well as by
ADAM10 and -17 inhibitors ... Taken together, our data suggest that in addition to functioning as an EGFR downstream effector, ERK1/2 also mediates
ADAM dependent HB-EGF shedding and subsequent
EGFR transactivation in response to a variety of stimuli, including wounding and GPCR ligands
Bakken et al., J Vasc Surg 2009
:
To determine the
role of
ADAM in
EGFR transactivation by ATF in human vascular smooth muscle cells ( VSMC ) during cell migration
Kasina et al., Cell Prolif 2009
:
ADAM mediated amphiregulin shedding and
EGFR transactivation ... These data also show that CXCL12 mediated cellular proliferation requires
EGFR transactivation in a Src- and
ADAM dependent manner in non transformed prostate epithelial cells
Takaguri et al., Hypertension 2011
(Carotid Artery Injuries...) :
In conclusion,
ADAM17 activation is
involved in
epidermal growth factor receptor activation and subsequent neointimal hyperplasia after vascular injury
Sanchez-Guerrero et al., PloS one 2012
:
This study reports for the first time that Egr-1 induction by IL-1beta involves EGFR and
MMP/ADAM dependent
EGFR phosphorylation