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CSF2 — E2F5
Text-mined interactions from Literome
Zhu et al., J Virol 2005
(Neoplasms, Experimental) :
However, when compared in vivo in nude mouse xenograft tumor models,
E2F/GM/E3b spread through tumors to a greater extent,
resulted in higher peak
GM-CSF and total exposure levels in both tumor and serum, and was more efficacious than the E3-deleted virus ... Using the matched WI-38 ( parental ) and WI-38-VA13 ( simian virus 40 large T antigen transformed ) cell pair, GM-CSF was shown to be selectively produced in cells expressing high levels of E2F, indicating that the tumor-selective
E2F promoter
controlled E1A and
GM-CSF expression
Strom et al., Cell Growth Differ 1998
:
In these cells,
E2F-3 , E2F-4, and DP-1 are
regulated by both IL-3 and granulocyte
colony stimulating factor ( G-CSF ), whereas E2F-1 was expressed at low levels and was not regulated by either cytokine