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C1QA — CDC7

Text-mined interactions from Literome

Cragg et al., Blood 2004 (Lymphoma) : Here, we show that certain of these reagents ( rituximab and 1F5 ), which redistribute CD20 into membrane rafts, are bound efficiently by C1q , deposit C3b, and result in complement dependent cytotoxicity ( CDC )
Fiocco et al., Reumatismo 2005 (Rheumatic Diseases) : In order to explain the clinical differences observed when these agents are used in the `` real world '', which can arise from the respective PK characteristics ( kinetics, route and frequency of administration, type of TNF binding, effects on cytokines ) and PD responses and peculiar mechanisms of action, with distinctive immune function ( LFTa inactivation ; apoptosis induction, TNF immunoprecipitation, C1q binding and CDC induction ; Fc? cross linking and ADCC induction ), the dynamics of interaction of the two classes of neutralizing molecules with TNF, and the ability in restoring TNF homeostasis, are outlined
Phuan et al., J Biol Chem 2012 (Neuromyelitis Optica) : Measurements of C1q binding and complement attack complex ( C9neo ) supported the conclusion that the greatly enhanced CDC by OAPs is due to efficient, multivalent binding of C1q to clustered NMO-IgG on OAPs