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AKT3 — ECM1
Text-mined interactions from Literome
Kim et al., FEBS Lett 2005
:
In the presence of FGF2, which is normally required for proliferation in an undifferentiated state, inhibition of phosphatidylinositol 3-kinase
(PI3K)/Akt/PKB signal stimulated differentiation and
attenuated the expression of
extracellular matrix ( ECM ) molecules
Martínez-Salgado et al., Exp Cell Res 2006
:
Akt activation is higher in double KO fibroblasts than in heterozygotes ; inhibition of
Akt activation also
inhibits ECM synthesis ...
PI3K-Akt pathway activation may be
involved in the increase in
ECM synthesis observed in the absence of H- and N-Ras
Kang et al., Int J Mol Med 2008
(Cell Transformation, Neoplastic) :
ECM from fibroblasts in UVB-SIPS
activates FAK, ERK, and
AKT in HaCaT cells ... ERK and PI3K/AKT inhibitors inhibit
ECM induced ERK,
AKT activation and cell proliferation
Dai et al., PloS one 2012
(Acute Disease...) :
Here, we demonstrate for the first time that acute
ECM results in significantly reduced activation of protein kinase B ( PKB or Akt )
leading to decreased
Akt phosphorylation and inhibition of the glycogen kinase synthase ( GSK3ß ) in the brains of mice infected with Plasmodium berghei ANKA ( PbA ) compared to uninfected controls and to mice infected with the non-neurotrophic P. berghei NK65 ( PbN )