Zhong et al., Mol Cancer Ther 2010
(Prostatic Neoplasms) :
Induction of clusterin by AKT -- role in cytoprotection against docetaxel in prostate tumor cells
Jun et al., Exp Mol Med 2011
:
The protective effect of clusterin on H2O2 induced apoptosis is impaired by PI3K inhibitor LY294002, which effectively suppresses clusterin induced activation of Akt and GSK-3ß
Chaiwatanasirikul et al., Cell death & disease 2011
(Cell Transformation, Neoplastic) :
Secreted CLU , which is selectively increased after transformation, activates the survival factor AKT , whereas intracellular CLU inhibits the activity of the oncogenic transcription factor nuclear factor kappa B