Gene interactions and pathways from curated databases and text-mining

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AGTR2 — DIANPH

Text-mined interactions from Literome

Andersen et al., Curr Hypertens Rep 2002 (Diabetic Nephropathies...) : The recently published clinical trials, based on angiotensin II receptor blockers ' effects on diabetic nephropathy and essential hypertension, have also shown significant endpoint reduction
Carey et al., Trends Endocrinol Metab 2003 (Diabetic Nephropathies) : ANG II type-1 ( AT(1) ) and type-2 ( AT(2) ) receptors are downregulated in chronic diabetes, but decreased AT(2) receptor expression might contribute to early diabetic nephropathy by reducing AT(2) receptor mediated beneficial actions that are counter-regulatory to those of the AT(1) receptor
Tse et al., Lupus 2005 (Lupus Nephritis...) : Angiotensin converting enzyme inhibitor ( ACEI ) or angiotensin II receptor blocker ( ARB ) reduces proteinuria and the rate of renal function deterioration in diabetic nephropathy and other glomerular diseases, but its role in quiescent lupus nephritis has not been established