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HDC — IL3
Text-mined interactions from Literome
Schneider et al., Exp Hematol 1999
:
IL-3 induced coexpression of
histidine decarboxylase , IL-4 and IL-6 mRNA by murine basophil precursors
Yamaguchi et al., Toxicology 2000
(Inflammation) :
Induction of
histidine decarboxylase , the histamine forming enzyme, in mice by
interleukin-12
Nakano et al., Nihon Yakurigaku Zasshi 2001
:
Among the cytokines tested, GM-CSF or
IL-3 specifically
augmented the LPS dependent
HDC induction by M phi
Wu et al., Int Immunopharmacol 2004
:
Histamine production via mast cell independent induction of
histidine decarboxylase in
response to lipopolysaccharide and
interleukin-1
Minkowski et al., Exp Hematol 1990
:
It results from an increase in histamine synthesis because of 1 ) the low level of histamine cell content before any incubation, 2 ) the parallel increase in both extra- and intracellular histamine levels in response to rhIL-3, and 3 ) the early
IL-3 induced increase in
L-histidine decarboxylase ( HDC ; EC 4.1.1.22 ) activity
Schneider et al., J Immunol 1987
:
Interleukin 3 and granulocyte-macrophage colony stimulating factor
induce de novo synthesis of
histidine decarboxylase in hemopoietic progenitor cells ... In response to GM-CSF, HDC activation is more rapid, with a significant enhancement after 4 hr of incubation, as compared with
IL-3 induced
HDC activation ... These results suggest that
IL-3 and GM-CSF
induce HDC activation in two distinct ways, possibly reflecting the involvement of distinct target cells ... Finally, the observation that cholera toxin, prostaglandin E2, and N6,2'-O-dibutyryl adenosine 3',5'-cyclic monophosphate mimic the
effects of
IL-3 and GM-CSF on bone marrow cell
HDC suggests an involvement of cyclic adenosine monophosphate in factor induced histamine producing cell stimulating activity
Endo et al., Br J Pharmacol 1995
:
Effects of macrophage depletion on the
induction of
histidine decarboxylase by lipopolysaccharide,
interleukin 1 and tumour necrosis factor
Salachas et al., Blood 1994
:
( 2 ) Neither
IL-3 nor IgE induced histamine production in the
presence of the specific inhibitor of
histidine decarboxylase (HDC) , the histamine forming enzyme ... ( 3 ) Both the enzymatic activity and the mRNA expression of
HDC were enhanced in
response to
IL-3 or IgE
Endo et al., Calcif Tissue Int 1993
(Bone Resorption) :
As granulocyte and granulocyte-macrophage colony stimulating factors and
interleukin-3 induce
HDC in hematopoietic organs, and histamine has a hematopoietic activity, the HDC induction by aminobisphosphonates may be relevant to the proliferation of progenitor cells of macrophages, granulocytes, and osteoclasts
Takamatsu et al., J Immunol 1996
:
GM-CSF and
IL-3 also
caused a marked accumulation of both
histidine decarboxylase and IL-6 mRNAs in the cells