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EGF — PLCG2

Text-mined interactions from Literome

Suzuki et al., J Cell Physiol 2001 : Actin filament assembly and actin-myosin contractility are necessary for anchorage- and EGF dependent activation of phospholipase Cgamma
Haendeler et al., J Biol Chem 2003 : GIT1 mediates Src dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor
Tamama et al., Stem Cells 2006 : During our examination of key signaling intermediaries, EGF caused robust phosphorylation of extracellular signal regulated protein kinase ( ERK ) and protein kinase B/akt ( AKT ) but only minimal phosphorylation of EGFR and phospholipase C-gamma in rat BMMSCs, whereas in the human BMMSCs these intermediaries were all strongly activated
Yang et al., J Biol Chem 1991 : Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor induced activation of phospholipase C-gamma in rat hepatocytes
Huckle et al., Endocrinology 1990 : Protein kinase C inhibits epidermal growth factor dependent tyrosine phosphorylation of phospholipase C gamma and activation of phosphoinositide hydrolysis
Bunney et al., Mol Cell 2009 : Based on this structure, we illustrate distinct requirements for PLCgamma(2) activation by Rac and EGF and generate Rac effector mutants that specifically block activation of PLCgamma(2), but not the related PLCbeta(2) isoform
Everett et al., J Biol Chem 2009 : Importantly, the activation of the ALI14-PLC gamma 2 and corresponding PLC gamma 1 variants was enhanced in response to EGF stimulation and bypassed the requirement for phosphorylation of critical tyrosine residues
Decker et al., J Biol Chem 1990 : EGF stimulated phosphorylation of phospholipase C-gamma on serine and tyrosine residues in cells expressing wild-type of Ala-654 receptors ... However, TPA treatment of cells inhibited EGF induced tyrosine phosphorylation of phospholipase C-gamma only in cells expressing wild-type receptors
Fenton et al., Mol Biol Cell 1993 : Furthermore, levels of EGF stimulated tyrosine phosphorylation of the EGF-R ( 170 kDa ) and phospholipase C gamma ( 145 kDa ) are dramatically decreased in cells treated with PRL
Chen et al., Life Sci 1993 (Carcinoma, Squamous Cell) : Taken together, the results suggest that EGF induced growth inhibition of A431 cells may be due to a quantitative changes of EGF-receptor tyrosine kinase activity in areas other than the recruitment and activation of phosphatidylinositol-specific phospholipase C gamma