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CASP1 — P2RX7
Text-mined interactions from Literome
Rothwell et al., Brain Behav Immun 2003
(Brain Injuries) :
Release and cleavage of active IL-1 beta may be achieved via purinergic
P2X7 receptors and
activation of
caspase-1
Colomar et al., J Biol Chem 2003
:
IL-1beta converting enzyme (ICE) , the caspase responsible for the maturation of pro-IL-1beta in IL-1beta, was
activated by
P2X7 receptor stimulation
Kahlenberg et al., J Immunol 2005
:
Stimulation of the
P2X7 receptor (P2X7R) , an ATP gated ion channel,
triggers rapid activation of
caspase-1 ... In this study we demonstrate that pretreatment of primary and Bac1 murine macrophages with TLR agonists is required for
caspase-1 activation by
P2X7R but it is not required for activation of the receptor itself ... This priming by LPS is dependent on protein synthesis, given that cyclohexamide blocks the ability of LPS to prime macrophages for
activation of
caspase-1 by the
P2X7R ... This protein synthesis is likely mediated by NF-kappaB, as pretreatment of cells with the proteasome inhibitor MG132, or the IkappaB kinase inhibitor Bay 11-7085 before LPS stimulation blocks the ability of LPS to potentiate the
activation of
caspase-1 by the
P2X7R
Verhoef et al., J Immunol 2005
:
Inhibitory effects of chloride on the
activation of
caspase-1 , IL-1beta secretion, and cytolysis by the
P2X7 receptor
Raffaghello et al., Cancer Res 2006
(Neuroblastoma) :
In contrast to the usual response typically observed in the majority of cell types,
P2X(7) in vitro stimulation did not
induce caspase-3 activation or apoptosis of neuroblastoma cells but rather supported their proliferation
López-Castejón et al., Mol Immunol 2007
(Ion Channel Gating) :
These findings indicate that
P2X(7) receptor
mediated activation of
ICE and release of IL-1beta result from different downstream signaling pathways and suggest that although the mechanisms involved in IL-1beta secretion are conserved throughout evolution, distinct inflammatory signals have been selected for the secretion of this cytokine in different vertebrates
Pelegrin et al., EMBO J 2006
:
Here, we identify pannexin-1, a recently described mammalian protein that functions as a hemichannel when ectopically expressed, as this dye-uptake pathway and show that signalling through pannexin-1 is required for processing of
caspase-1 and release of mature IL-1beta
induced by
P2X(7) receptor activation
Delarasse et al., J Neurochem 2009
(Necrosis) :
Prolonged activation of
P2X7R with these nucleotides
leads to
caspase independent death of NPCs. P2X7R ligation induces NPC lysis/necrosis demonstrated by cell membrane disruption accompanied with loss of mitochondrial membrane potential
Muñoz-Planillo et al., J Immunol 2009
(Inflammation...) :
Notably,
caspase-1 activation induced by S. aureus supernatant was
independent of the
P2X7 receptor and the essential TLR adaptors MyD88 and TIR domain containing adapter inducing IFN-beta, but was inhibited by extracellular K ( + )
Harder et al., J Immunol 2009
(Disease Models, Animal...) :
Unlike activation of the Nlrp3 inflammasome by TLR ligands, the induction of
caspase-1 activation by S. pyogenes did not
require exogenous ATP or the
P2X7R
Cesaro et al., Am J Physiol Gastrointest Liver Physiol 2010
(Inflammatory Bowel Diseases) :
The aims of the present study were 1 ) to examine P2X(7)R expression in IEC ( T84 cells ) and in human intestinal biopsies ; 2 ) to detect any changes in P2X(7)R expression in T84 cells during PMNL transepithelial migration, and during the active and quiescent phases of IBD ; and 3 ) to test whether
P2X(7)R stimulation in T84 monolayers can
induce caspase-1 activation and IL-1beta release by IEC
Liao et al., J Leukoc Biol 2013
:
Moreover, statin induced
caspase-1 activation and IL-1ß production in LPS primed THP-1 cells are
dependent on GGPP deficiency and
P2X7 activation