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MAPK8 — NFATC1
Pathways - manually collected, often from reviews:
-
BioCarta nfat and hypertrophy of the heart :
JNK1 (MAPK8)
→
NFATc (NFATC1)
(modification, activates)
-
BioCarta nfat and hypertrophy of the heart :
JNK1 (MAPK8)
→
NFATc (NFATC1)
(modification, activates)
-
NCI Pathway Database Role of Calcineurin-dependent NFAT signaling in lymphocytes:
CaM/Ca2+/Calcineurin A alpha-beta B1 complex (CALM2)
→
NFATc/JNK1 complex (NFATC1-MAPK8)
(modification, collaborate)
Porter et al., J Biol Chem 2000*, Chow et al., Mol Cell Biol 2000*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Role of Calcineurin-dependent NFAT signaling in lymphocytes:
NFATc/JNK1 complex (NFATC1-MAPK8)
→
JNK1 (MAPK8)
(modification, collaborate)
Porter et al., J Biol Chem 2000*, Chow et al., Mol Cell Biol 2000*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Role of Calcineurin-dependent NFAT signaling in lymphocytes:
NFATc/JNK1 complex (NFATC1-MAPK8)
→
NFATc (NFATC1)
(modification, collaborate)
Porter et al., J Biol Chem 2000*, Chow et al., Mol Cell Biol 2000*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Role of Calcineurin-dependent NFAT signaling in lymphocytes:
JNK1 (MAPK8)
→
NFATc (NFATC1)
(modification, collaborate)
Porter et al., J Biol Chem 2000*, Chow et al., Mol Cell Biol 2000*
Evidence: mutant phenotype, assay, physical interaction
-
WikiPathways MAPK Signaling Pathway:
MAPK8/MAPK10/MAPK9
→
NFATC1
(mim-inhibition)
Text-mined interactions from Literome
Wu et al., Mol Cell Biol 2003
:
Fourth, p38
MAPK promoted the interaction of
NFATc with the coactivator CREB binding protein ... All together, the overall
effect of p38
MAPK on
NFATc in T cells is clear activation
Holsinger et al., Curr Biol 1998
:
Activation of Jun N-terminal kinase or stress activated kinase ( JNK or SAPK ) and
mitogen activated protein kinase ( MAPK ) and the
induction of the transcription factor
NF-ATc1 and egr-1 genes was normal