Chen et al., J Immunol 2000
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The TNF-alpha induced, but not the TPA induced, COX-2 promoter activity was inhibited by phospholipase C-gamma2 mutants, and the COX-2 promoter activity induced by either agent was attenuated by dominant negative mutants of PKC-alpha, NF-kappaB inducing kinase, or I-kappaB ( inhibitory protein that dissociates from NF-kappaB ) kinase ( IKK ) 1 or 2
Shen et al., J Mol Cell Cardiol 2007
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The purpose of this study was to investigate the role of phosphatidylinositol ( PI ) -phospholipase Cgamma1 ( PLCgamma1 ) in cardiac COX-2 expression in vitro and in vivo