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ANGPT2 — PTGS2

Text-mined interactions from Literome

Ohnaka et al., Hypertension 2000 : In the present study, we investigated whether Ang II regulates COX-2 expression in cultured rat vascular smooth muscle cells ( VSMCs ) ... Ang II did not increase transcription of the COX-2 gene, as examined with a COX-2 promoter/luciferase chimeric plasmid construct ... These results suggest that Ang II regulates COX-2 expression and PG production and modulates cell proliferation through MAPK mediated signaling pathways in rat VSMCs
Höcherl et al., Pflugers Arch 2001 : In summary, these findings, obtained when the renin system was activated by AT1 receptor blockade, indicate that Ang II is not required to stimulate COX-2 expression and that COX-2 activity is not required to stimulate renin expression
Hu et al., J Pharmacol Exp Ther 2002 : ANG II increased transcription of the COX-2 gene ; also, nuclear extracts from stimulated cells had increased NF-kappa B binding to its DNA consensus sequence ... Not only did ANG II increase COX-2 expression and prostaglandin synthesis, ANG II-stimulated DNA synthesis and cell migration were dependent on COX-2 activity ... These results suggest that ANG II enhances COX-2 expression at the transcription level ; also, COX-2 activity plays an important role in mediating ANG II- induced proliferation and migration of VSMCs, suggesting the possibility of magnification of ANG II effects over time due to the induction of COX-2 expression
Castrop et al., American journal of physiology. Renal physiology 2003 (Renal Artery Obstruction) : Because across-the-board data indicate that renin and cyclooxygenase-2 (COX-2) expression in the kidney cortex are regulated in parallel and because ANG II can inhibit COX-2 expression, the purpose of our study was to characterize a potential general inhibitory feedback of the renin-angiotensin system on renocortical COX-2 expression in vivo
Jaimes et al., Kidney Int 2005 : We designed studies to determine ( 1 ) whether Ang II induces COX-2 in the glomerulus in vivo in the glomerulus as well as in vitro in mesangial cells, ( 2 ) whether ROS originated from Ang II are involved, and ( 3 ) whether COX-2 derived prostaglandins modulate the growth promoting effects of Ang II in mesangial cells
Wang et al., Cancer Lett 2006 (Anoxia...) : We investigated the potential effect of Cyclooxygenase-2 (Cox-2) on hypoxia induced Angiopoietin-2 (Ang-2) expression in gastric cancer cells
Helle et al., American journal of physiology. Renal physiology 2006 (Hypertension, Renovascular) : COX-2 inhibition with NS-398 did not increase the ANG II-mediated Cai2+ response in any of the groups
Battle et al., Cancer Res 2006 : IFN-gamma blocks the biological activity of VEGF through inhibition of genes necessary for the VEGF response, including angiopoietin-2 , urokinase plasminogen activator, tissue inhibitor of matrix metalloproteinase-1, cyclooxygenase-2 , and VEGF receptor 2
Theilig et al., American journal of physiology. Renal physiology 2006 (Disease Models, Animal...) : ANG II receptor blockade confirmed negative regulation of COX-2 by ANG II but blunted the decrease in COX-1 selectively in nonclipped kidneys
Pham et al., J Cell Physiol 2008 : Expression of a dominant negative CREB mutant inhibited Ang II- and EGF dependent induction of the COX-2 promoter
Pham et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : Cyclooxygenase-2 (COX-2) is rapidly induced by angiotensin (Ang)-II in the non-tumorigenic, rat intestinal epithelial cell line, IEC-18, through its G-protein coupled receptor, AT1R
Tani et al., Mol Cell Biochem 2008 : In order to clarify the role of Ang II in COX-2 expression in the intestinal epithelium, the receptor subtype-specific effect on COX-2 expression in a rat intestinal epithelial cell line ( RIE-1 ) has been investigated ... Ang II and lipopolysaccharide (LPS) additively induced COX-2 protein in RIE-1 cells, whereas the LPS induced COX-2 expression was significantly attenuated by low concentrations of Ang II or the AT(2) agonistic peptide CGP-42112A only in AT(2) over expressed cells ... These data indicate that Ang II bi-directionally regulates COX-2 expression via both AT(1) and AT(2) receptors
Matsuzuka et al., Mol Cell Biochem 2009 (Lung Neoplasms) : We also compared the efficiencies of Ang II-dependent COX-2 induction in lung epithelial cells and stromal cells ... Ang II induced COX-2 expression in lung fibroblasts in a dose dependent manner ( 10 ( -9 ) to 10 ( -7 ) M ) through the Ang II subtype 1 receptor ( AT(1) ) ... In addition, Ang II synergistically stimulated the induction of COX-2 by pro-inflammatory cytokines, IL-1beta, or TNF-alpha
Kane et al., Pflugers Arch 2010 : Ang II increased the expression of COX-1 and COX-2 in the aortic wall
Zack et al., Atherosclerosis 2011 (Aortic Aneurysm, Abdominal...) : Ang II induction of cyclooxygenase-2 , interleukin-6, matrix metalloproteinase (MMP)-2, MMP-13 and MMP-14 was reduced significantly in GX DKO mice compared to apoE ( -/- ) mice
Galán et al., J Hypertens 2011 : Ang II did not modify COX-2 transcriptional activity but increased COX-2 mRNA stability in IL-1ß treated cells ; by contrast, it increased PGIS mRNA levels through a transcriptional mechanism