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HSPG2 — PTEN
Text-mined interactions from Literome
Mhashilkar et al., Mol Ther 2003
(Breast Neoplasms...) :
Expression of the PI3K pathway members ( p85 PI3K, FAK, ILK-1, Akt, and
PLC-gamma ) was downregulated and expression of the PI3K antagonist
PTEN was
increased
Alvarez-Breckenridge et al., Hum Mol Genet 2007
(Breast Neoplasms) :
As phospholipase C (PLC) is both involved in PLD activation and is regulated by PIP2/3 levels, we investigated the
role of
PTEN on
PLC activation
van Haastert et al., J Cell Biol 2007
:
This suggest that PI3-kinase mediated chemotaxis is
regulated by
PLC , probably through controlling PIP ( 2 ) levels and
phosphatase and tensin homologue (PTEN) activity, whereas chemotaxis mediated by PLA2 appears to be controlled by intracellular Ca ( 2+ )
Wang et al., J Am Chem Soc 2008
:
To explore the specificity of these types of molecules, we have synthesized D-3-deoxydioctanoylphosphatidylinositol ( D-3-deoxy-diC8PI ), D-3,5-dideoxy-diC8PI, and D-3-deoxy-diC8PI-5-phosphate and their enantiomers, characterized their aggregate formation by novel high-resolution field cycling ( 31 ) P NMR, and examined their susceptibility to
phospholipase C (PLC) , their
effects on the catalytic activities of PI3K and
PTEN against diC8PI and diC8PI-3-phosphate substrates, respectively, and their ability to induce the death of U937 human leukemic monocyte lymphoma cells