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IL6 — NPPA
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Tanaka et al., Res Commun Mol Pathol Pharmacol 2001
(Body Weight...) :
Primary cultures of neonatal rat cardiac myocyte showed that
IL-6 increased
ANP and BNP mRNA expression in a dose-responsive fashion
Tanaka et al., J Int Med Res 2004
:
We investigated the
effect of
interleukin-6 (IL-6) expression on sarco/endoplasmic reticulum Ca ( 2+ ) -ATPase ( SERCA ),
atrial natriuretic peptide (ANP) and B-type natriuretic peptide ( BNP ) mRNA levels in cultured rat neonatal ventricular myocytes
Moro et al., Diabetologia 2007
(Inflammation...) :
ANP directly
inhibited the secretion of
IL-6 and monocyte chemoattractant protein-1 by macrophages
Turkyilmaz et al., Inflammation 2007
(Disease Models, Animal...) :
The induction of
ANP resulted in a significant increase in the mortality rate, pancreatic necrosis, serum activity of amylase, alanine aminotransferase ( ALT ), and
interleukin-6 (IL-6) , lactate dehydrogenase ( LDH ) in bronchoalveolar lavage (BAL) fluid, serum concentration of urea, and tissue activity of myeloperoxidase (MPO) and maondialdehyde ( MDA ) in the pancreas and lung, and a significant decrease in concentrations of calcium, blood pressure, urine output and p0 ( 2 )
Walsh et al., Cancer Biol Ther 2010
(Breast Neoplasms...) :
In vitro,
PND-1186 reduced tumor necrosis factor-a
triggered interleukin-6 cytokine expression, indicating that FAK inhibition may impact tumor progression via effects on both tumor and stromal cells