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INS — NEUROG3

Text-mined interactions from Literome

Treff et al., Stem Cells 2006 : Moreover, we find that Ngn3 induction in differentiating ESCs results in significant increases in insulin , glucagon, and somatostatin expression
Yamamoto et al., Diabetologia 2006 : Adenovirus mediated expression of ngn3 ( also known as Neurog3 ) and Ptf1a in these cells induced expression of insulin and somatostatin, and of carboxypeptidase A, respectively
Ogihara et al., Endocr J 2008 : Coexpression of Nkx6.1 and Ngn3 induced endogenous expression of the insulin 2 gene, while coexpression of Maf A and Ngn3 induced both insulin 1 and 2 genes in AR42J-B13 cells
Yechoor et al., Dev Cell 2009 (Diabetes Mellitus, Experimental) : Here, we show that hepatic gene transfer of Ngn3 transiently induces insulin in terminally differentiated hepatocytes but fails to transdifferentiate them, i.e., switch their lineage into islet cells
Koblas et al., Transplant Proc 2010 : Reverse transcriptase polymerase chain reaction ( RT-PCR ) analysis revealed that insulin-like growth factor-1 (IGF-1) , epidermal growth factor (EGF), and Exendin-4 significantly increased the expression of the transcription factor neurogenin-3 , whereas the expressions of pancreatic and duodenal homeobox 1 ( PDX-1 ), neurogenic differentiation 1 (NeuroD) were increased only among samples treated with ZnCl2 and not significantly affected by treatment with the tested growth factors