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GLIS3 — INS

Text-mined interactions from Literome

Yang et al., Nucleic Acids Res 2009 (Congenital Hypothyroidism...) : The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription ... We demonstrate that insulin 2 (Ins2) mRNA expression in rat insulinoma 832/13 cells is markedly increased by wild-type Glis3 overexpression, but not by the NDH1 mutant ... Glis3 also may indirectly affect insulin promoter activity through upregulation of MafA and downregulation of Nkx6-1 ... This study uncovers a role of Glis3 for regulation of insulin gene expression and expands our understanding of its role in the beta cell
ZeRuth et al., J Biol Chem 2011 : We further showed that SUFU is able to inhibit the activation of the insulin promoter by Glis3 but not the activation by a Glis3 mutant deficient in its ability to bind SUFU, suggesting that the inhibitory effect is dependent on the interaction between the two proteins
Nogueira et al., PLoS Genet 2013 (Diabetes Mellitus, Type 1...) : GLIS3 plays a role in the generation of pancreatic beta cells and in insulin gene expression, but there is no information on the role of this gene on beta cell viability and/or susceptibility to immune- and metabolic induced stress