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CYP7A1 — INS

Text-mined interactions from Literome

Li et al., J Biol Chem 2006 : Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes : roles of forkhead box O1 and sterol regulatory element binding protein 1c ... The objective of this study is to elucidate the mechanism of insulin regulation of cholesterol 7alpha-hydroxylase gene expression in human hepatocytes
Ponugoti et al., Mol Endocrinol 2007 : Insulin inhibits transcription of cholesterol 7alpha-hydroxylase ( Cyp7a1 ), a key gene in bile acid synthesis, and the hepatic nuclear factor-4 ( HNF-4 ) site in the promoter was identified as a negative insulin response sequence
Li et al., J Lipid Res 2008 : Previous studies show that TGFbeta1, TNFalpha, and insulin inhibit cholesterol 7alpha-hydroxylase ( CYP7A1 ) gene transcription and bile acid synthesis in human hepatocytes ... In streptozotocin induced diabetic rats, Cyp7a1 mRNA expression levels were induced and insulin attenuated CYP7A1 mRNA levels
Li et al., Biochim Biophys Acta 2009 (Insulin Resistance) : Insulin caused rapid exclusion of FoxO1 from the nucleus and resulted in the induction of CYP7A1 mRNA expression, which was blocked by FoxO1-ADA
Wang et al., J Lipid Res 1996 : Thus, human cholesterol 7 alpha-hydroxylase gene promoter is strongly repressed by insulin , PMA, and steroid/thyroid hormones and results in the low level of cholesterol 7 alpha-hydroxylase expression in the human liver