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GRAP2 — NFKBIA

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Wang et al., Allergy 2005 : IL-6 gene expression was assessed by reverse transcriptase-polymerase chain reaction ( RT-PCR ), and p38 MAPK activity and inhibitor (I)kappaB-alpha induction were evaluated by Western blot
Singleton et al., Shock 2005 (MAP Kinase Signaling System...) : GLN given 1 h postsepsis led to inhibition of lung tissue NF-kappaB activation ( P < 0.001 vs. SP ), attenuated degradation of IKBalpha , and inhibited phosphorylation of p38 MAPK, and ERK, pathways critical for cytokine release
Kanayama et al., J Endotoxin Res 2007 : Here, we show that bikunin : ( i ) blocks LPS induced secretion of pro-inflammatory cytokines, including TNF-alpha and IL-1beta, in a dose dependent manner ; ( ii ) has an inhibitory effect on cytokine production at a concentration of 0.2 microM, reaching 65 % inhibition at the highest doses of bikunin tested ( 5 microM ) ; ( iii ) has the suppressive capacity of ERK1/2 and p38 signaling pathways ; and ( iv ) inhibited sequentially the LPS induced phosphorylation of IkappaB-alpha , degradation of IkappaB-alpha, and nuclear translocation of NF-kappaB