◀ Back to EGFR
EGFR — HDAC6
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
EGFR
—
HDAC6
(colocalization, biochemical)
Gao et al., J Biol Chem 2010*
-
IRef Biogrid Interaction:
EGFR
—
HDAC6
(physical association, affinity chromatography technology)
Gao et al., J Biol Chem 2010*
-
IRef Intact Interaction:
EGFR
—
HDAC6
(physical association, ubiquitin reconstruction)
Deribe et al., Science signaling 2009
-
IRef Intact Interaction:
EGFR
—
HDAC6
(phosphorylation reaction, protein kinase assay)
Deribe et al., Science signaling 2009
-
IRef Intact Interaction:
EGFR
—
HDAC6
(physical association, anti tag coimmunoprecipitation)
Deribe et al., Science signaling 2009
-
IRef Intact Interaction:
EGFR
—
HDAC6
(physical association, anti bait coimmunoprecipitation)
Deribe et al., Science signaling 2009
-
IRef Intact Interaction:
Complex of HSPA1A-HDAC6-AP2A1-EGFR-MAP3K12
(association, anti bait coimmunoprecipitation)
Deribe et al., Science signaling 2009
Text-mined interactions from Literome
Kim et al., Radiother Oncol 2009
(Neoplasms) :
Conversely, ectopic overexpression of
HDAC6 isotype
increased the levels of
p-EGFR and p-AKT expression, and reduced LBH589 mediated radiosensitization
Gao et al., J Biol Chem 2010
:
The microtubule associated
histone deacetylase 6 (HDAC6) regulates
epidermal growth factor receptor (EGFR) endocytic trafficking and degradation ... We found that loss of
HDAC6 promoted
EGFR degradation
Liu et al., PloS one 2012
:
We present for the first time that
histone deacetylase 6 (HDAC6) regulates
EGFR degradation and trafficking along microtubules in Pkd1 mutant renal epithelial cells
Arsenault et al., PloS one 2013
(Anoxia...) :
Our data provide evidence that hypoxia influences invadopodia formation in a biphasic manner, which involves the
activation of
HDAC6 deacetylase activity by
EGFR , resulting in enhanced Smad phosphorylation and nuclear accumulation