◀ Back to E2F1
E2F1 — TRIM28
Pathways - manually collected, often from reviews:
-
NCI Pathway Database E2F transcription factor network:
E2F1/DP complex (E2F1-TFDP2_TFDP1)
→
KAP1 (TRIM28)
(transcription, activates)
Wang et al., Nat Cell Biol 2006, Wang et al., J Biol Chem 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database E2F transcription factor network:
E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1)
→
KAP1 (TRIM28)
(transcription, activates)
Ma et al., J Biol Chem 2003, Wang et al., J Biol Chem 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database E2F transcription factor network:
E2F1/DP complex (E2F1-TFDP2_TFDP1)
→
KAP1 (TRIM28)
(transcription, activates)
Wang et al., J Biol Chem 2005*, Wang et al., J Biol Chem 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database E2F transcription factor network:
E2F1/DP complex (E2F1-TFDP2_TFDP1)
→
KAP1 (TRIM28)
(modification, collaborate)
Wang et al., J Biol Chem 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database E2F transcription factor network:
KAP1 (TRIM28)
→
E2F1/DP/HDAC1 complex (E2F1-TFDP2_TFDP1-HDAC1)
(modification, activates)
Wang et al., J Biol Chem 2007
Evidence: mutant phenotype, assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wang et al., J Biol Chem 2007
:
Ectopic expression of
KAP1 represses
E2F1 transcription and apoptosis functions independent of pRb ... Depletion of endogenous
KAP1 in pRb-deficient Saos2 cells by RNA interference
increases E2F1 acetylation level, stimulates E2F1 transcriptional activity, and sensitizes apoptosis response to DNA damage ... Therefore,
KAP1 contributes to the negative regulation of
E2F1 and may serve as a partial backup to prevent E2F1 mediated apoptosis in the absence of pRb
Hu et al., J Biol Chem 2012
:
Moreover,
KAP1 Ser-473 phosphorylation induced by DNA damage
stimulated KAP1-E2F1 binding