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CDKN1A — CNTN2

Text-mined interactions from Literome

de La Fuente et al., J Virol 2000 (HTLV-I Infections...) : Wild-type but not a mutant form of Tax ( M47 ) transactivated the p21/waf1 promoter in a p53 independent manner and utilized a minimal promoter that contained E2A and TATA box sequences
de La Fuente et al., AIDS Res Hum Retroviruses 2000 : We found that the minimal p21/waf1 promoter ( -49 to +49 sequence ) was activated by Tax and the minimal promoter contained two E2A transcription factor binding sites located between the TATA box and the initiation site
Chowdhury et al., Int J Cancer 2003 : We investigated the possible involvement of HTLV-1 Tax in the transcriptional activation of p21/Waf1/Cip1 ( hereafter p21 ), a potent inhibitor of cyclin dependent kinases and cell growth ... CREB/ATF defective Tax mutant ( M47 ) activated the p21 promoter significantly less efficiently ... Tax activated wild type ( wt ) p21 promoter in p53 negative Jurkat and p53 positive A301cells, irrespective of endogenous p53 status, and activated a mutant p21 promoter containing a p53 responsive element (p53RE) deletion as strongly as wt promoter ... Of importance, cdk2 activity was almost completely abolished in Tax induced p21 expressing MT-2 cells, suggesting that Tax induced p21 predominantly affects the activity of cdk2, a late G1 and S phase kinase ... Taken together, these findings suggest that HTLV-1 Tax activates p21/Waf1/Cip1 , a cell growth inhibitor, in a p53 independent mechanism through CREB/ATF related transcription factors, and inhibits cdk2 ... Tax induction of p21 may balance the T-cell proliferation function of Tax and may contribute to the long clinical latency of HTLV-1 infection and the delayed development of adult T-cell leukemia
Sieburg et al., J Virol 2004 : Tax1 markedly activated transcription from the cdk inhibitor p21 ( cip1/waf1 ) promoter in comparison to Tax2, suggesting that upregulation of p21 ( cip1/waf1 ) may account for the differential inhibition of cellular replication kinetics displayed by Tax1/Jurkat and Tax2/Jurkat cells
Kuo et al., EMBO J 2006 (Cell Transformation, Viral) : These results indicate that APC activation by Tax causes inactivation of SCF ( Skp2 ) and stabilization of p21 ( CIP1/WAF1 ) and p27 ( KIP1 )
Akagi et al., Oncogene 1996 (Leukemia, T-Cell) : Expression of cell-cycle regulatory genes in HTLV-I infected T-cell lines : possible involvement of Tax1 in the altered expression of cyclin D2, p18Ink4 and p21Waf1/Cip1/Sdi1
Cereseto et al., Blood 1996 (Cell Transformation, Viral) : Additionally, Tax induces upregulation of a p21waf1/cip1 promoter-driven luciferase gene in p53 null cells, and increases p21waf1/cip1 expression in Jurkat T cells