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CCL2 — NOX1
Text-mined interactions from Literome
Brandes et al., Thromb Haemost 2001
(MAP Kinase Signaling System) :
Thrombin induced
MCP-1 expression
involves activation of the p22phox containing
NADPH oxidase in human vascular smooth muscle cells
Brandes et al., Antioxid Redox Signal 2003
:
By influencing the activity of p38 mitogen activated protein kinase and AKT,
NADPH oxidase derived O ( 2 ) .-
increases the expression of several pro-arteriosclerotic genes, such as
monocyte chemoattractant protein-1 , tissue factor, and vascular endothelial growth factor
Yamagishi et al., Drugs Exp Clin Res 2003
:
Nifedipine
inhibits tumor necrosis factor-alpha induced
monocyte chemoattractant protein-1 overexpression by blocking
NADPH oxidase mediated reactive oxygen species generation ... The results demonstrate that nifedipine could
inhibit TNF-alpha induced
MCP-1 overexpression in HUVEC by suppressing
NADPH oxidase mediated ROS generation
Tölle et al., Arterioscler Thromb Vasc Biol 2008
:
HDL associated lysosphingolipids inhibit
NAD ( P ) H oxidase dependent
monocyte chemoattractant protein-1 production
Turchan-Cholewo et al., Antioxid Redox Signal 2009
:
Furthermore, inhibition of
NADPH oxidase attenuated Tat induced release of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF), and
monocyte chemoattractant protein 1 ( MCP-1 ), and decreased microglial mediated neurotoxicity
Zhang et al., Nephrology (Carlton) 2009
:
Role of
NAD ( P ) H oxidase in transforming growth factor-beta1 induced
monocyte chemoattractant protein-1 and interleukin-6 expression in rat renal tubular epithelial cells ... This study investigated the
role of
NAD ( P ) H oxidase in transforming growth factor-beta1 ( TGF-beta1 ) -induced reactive oxygen species ( ROS ) generation,
monocyte chemoattractant protein-1 ( MCP-1 ), and interleukin-6 (IL-6) expression in rat renal tubular epithelial NRK-52E cells
Zhang et al., Invest Ophthalmol Vis Sci 2009
(Diabetes Mellitus, Experimental...) :
NAD ( P ) H oxidase dependent regulation of
CCL2 production during retinal inflammation ... In this study, the
role of
NAD ( P ) H oxidase in
CCL2 production was assessed ... Analysis of downstream signals showed that inhibition of
NAD ( P ) H oxidase partially inhibited NF-kappaB activation but did not
reduce CCL2 mRNA stability or prevent TNF-alpha induced phosphorylation of p38MAPK ...
NAD ( P ) H oxidase activity is
required for
CCL2 production during retinal vascular inflammation
Pan et al., Braz J Med Biol Res 2009
(Inflammation) :
These data suggest that the inhibition of
NAD ( P ) H oxidase dependent NF-kappaB signaling
reduces the increase in
MCP-1 production by GECs induced by Ang II
Chen et al., Zhonghua Bing Li Xue Za Zhi 2009
:
NADPH oxidase derived ROS is
involved in AngII induced
MCP-1 expression
Lee et al., Inflamm Res 2010
:
Role of
NADPH oxidase in interleukin-4 induced
monocyte chemoattractant protein-1 expression in vascular endothelium ... Additionally, pharmacological inhibitors of
NADPH oxidase ( NOX ) significantly
attenuated IL-4 induced
MCP-1 expression in HAEC
Cho et al., Inflamm Res 2011
(Inflammation...) :
To investigate whether
NADPH oxidase induces
MCP-1 expression and the activation of mitogen activated protein kinases ( MAPKs ) in H. pylori infected gastric epithelial cells ... Inhibiting
NADPH oxidase by DPI suppresses H. pylori
induced activation of MAPKs and
MCP-1 expression in AGS cells
Weaver et al., Mol Cell Endocrinol 2012
(Diabetes Mellitus) :
Inhibitors of NADPH oxidase, apocynin and diphenyleneiodonium, and a dual selective
NOX1/4 inhibitor,
blocked ROS generation ( p < 0.01 ) and induction of
MCP-1 ( p < 0.05 ) by pro-inflammatory cytokines in beta cells ... Inhibitors of
NADPH oxidase , apocynin and diphenyleneiodonium, and a dual selective NOX1/4 inhibitor,
blocked ROS generation ( p < 0.01 ) and induction of
MCP-1 ( p < 0.05 ) by pro-inflammatory cytokines in beta cells