Lee et al., J Endod 2009
(Alveolar Bone Loss...) :
On the other hand, Cyr61 treatment of MG-63 cells induced the release of CCL2 , a chemokine responsible for macrophage chemotaxis
Lin et al., J Endod 2009
(Alveolar Bone Loss...) :
Simvastatin also reduced the levels of TNF-alpha induced CCL2 , and exogenous Cyr61 restored the inhibitory effects
Lai et al., PloS one 2013
(Fibrosis...) :
Notably, the upregulation of Cyr61 in UUO kidneys was followed by a marked increase in monocyte chemoattractant protein 1 ( MCP-1 ) transcripts and macrophage infiltration, which were attenuated in mice treated with anti-Cyr61 antibodies