Tsuchida et al., Int J Obes Relat Metab Disord 2001
(Diabetes Mellitus...) :
These data indicate that BDNF rapidly regulates energy metabolism in obese diabetic animals, partly through activating the sympathetic nervous system and inducing UCP1 gene expression in BAT
Nonomura et al., Int J Exp Diabetes Res 2001
(Diabetes Mellitus...) :
BDNF enhanced norepinephrine turnover and increased uncoupling protein-1 mRNA expression in the interscapular brown adipose tissue
Wang et al., Am J Physiol Regul Integr Comp Physiol 2007
(Weight Gain) :
BDNF had no effect on SPA, but increased UCP1 gene expression in BAT at 6 h, but not 24 h after injection
Wang et al., Brain Res 2010
(Weight Gain) :
The purposes of the study were to determine : 1 ) if BDNF in the VMH increases energy expenditure ( EE ) ; 2 ) if BDNF enhanced thermogenesis results from increased spontaneous physical activity (SPA) and resting metabolic rate ( RMR ) ; and 3 ) if VMH BDNF thermogenic effects are mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) ... BDNF did not induce a significant increase in BAT UCP1 expression