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BDNF — CAPS2

Text-mined interactions from Literome

Sadakata et al., J Neurosci 2004 : Thus, we suggest that CAPS2 mediates the depolarization dependent release of NT-3 and BDNF from granule cells, leading to regulation in cell differentiation and survival during cerebellar development
Sadakata et al., J Comp Neurol 2006 : These results demonstrate that the CAPS family proteins are involved in the secretion of different secretory substances in developing and postnatal brains, and that CAPS2 is probably involved in BDNF secretion in many brain areas
Sadakata et al., J Histochem Cytochem 2007 : CAPS1 regulates catecholamine release from neuroendocrine cells, whereas CAPS2 is involved in the release of brain derived neurotrophic factor and neurotrophin-3 from cerebellar granule cells
Sadakata et al., Neurosci Res 2010 (Genetic Predisposition to Disease) : We found that CAPS2 is involved in the secretion of brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) and that CAPS2 KO mice not only have deficits in neuronal development and survival but also exhibit abnormal behaviors, including impaired social interaction, hyperactivity, an abnormal sleep-wake rhythm and increased anxiety in unfamiliar environments
Shinoda et al., Proc Natl Acad Sci U S A 2011 (Synaptic Transmission) : However, how CAPS2 affects BDNF secretion and its biological significance in inhibitory neurons are largely unknown ... Here we reveal the role of CAPS2 in the regulated secretion of BDNF and show the effect of CAPS2 on the development of hippocampal GABAergic systems