Zadran et al., J Neurosci 2010
:
Brain derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen activated protein kinase dependent phosphorylation ... BDNF stimulated m-calpain but not mu-calpain serine phosphorylation, an effect also blocked by MAPK inhibitors ... Our results indicate that, in cultured neurons, both BDNF and EGF activate m-calpain by MAPK mediated phosphorylation
Briz et al., J Neurosci 2013
:
BDNF also activates calpain , a calcium dependent cysteine protease, which has been shown to play a critical role in learning and memory