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APOB — LPA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lundstam et al., Arterioscler Thromb Vasc Biol 1999
(Arteriosclerosis) :
We found that association of
Lp(a) with matrix secreted by cultured human arterial smooth muscle cells
increased 2 to 3 times the subsequent specific binding of radioactive
LDL
Zhao et al., Clin Chim Acta 2000
:
Results showed that PDGF-B expression was not influenced by
n-LDL , but was moderately
increased by ox-LDL and
n-Lp(a)
Ryan et al., J Lipid Res 2000
:
Lipoprotein deprivation
stimulates transcription of the
CTP : phosphocholine cytidylyltransferase gene
Stenvinkel et al., Eur J Clin Invest 2000
(Albuminuria...) :
The present uncontrolled prospective study shows that
LDL-A causes a rapid 30-40 % decrease in serum cholesterol and plasma
Lp(a) levels in patients with NS
Zhao et al., Thromb Res 2000
:
Results showed that P-selectin protein expression was not influenced by
n-LDL , but was moderately
increased by ox-LDL and
n-Lp(a)
Gaubatz et al., J Lipid Res 2001
(Hypertriglyceridemia) :
Neither plasminogen nor
LDL inhibited binding of
Lp[a ] to TRL
Sun et al., J Biol Chem 2002
(Arteriosclerosis...) :
Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human
apolipoprotein ( a )
Chimienti et al., Clin Biochem 2003
(Helicobacter Infections...) :
We investigated whether the bacterium persistent inflammation or the expression of the
cytotoxin associated gene A (CagA) may
affect serum lipids as well as
Lipoprotein(a)
Wang et al., Nat Med 2003
(Brain Ischemia) :
Lipoprotein receptor
mediated induction of matrix metalloproteinase by
tissue plasminogen activator
Buechler et al., Biochim Biophys Acta 2003
(Coronary Artery Disease...) :
Lipoprotein (a) downregulates lysosomal acid lipase and
induces interleukin-6 in human blood monocytes
de Rijke et al., J Lipid Res 1992
:
In vitro studies show that the association and degradation of 125I labeled
Ox-Lp[a ] with liver endothelial and Kupffer cells was
inhibited by oxidized
LDL ( Ox-LDL ), poly I, or Ox-Lp[a ] itself by 60-90 %, while only a partial competition was found with acetylated-LDL ( up to 25 % )
Rifai et al., Clin Chem 2004
(Angina Pectoris...) :
High
Lp(a) predicts risk of angina, and the risk is substantially
increased with high concomitant
LDL-cholesterol
Snyder et al., J Biol Chem 1992
:
At 4 degrees C,
LDL receptor
mediated binding of both
Lp(a) and LDL was of low affinity, being 0.8 and 0.23 microM, respectively
Etingin et al., J Biol Chem 1991
(Thrombosis) :
Lipoprotein (a) regulates
plasminogen activator inhibitor-1 expression in endothelial cells
Genest et al., Am J Cardiol 1991
(Coronary Disease) :
Stepwise discriminant analysis revealed that
Lp(a) was a risk factor for the presence of CAD in men,
independent of smoking, hypertension, diabetes,
LDL and HDL cholesterol, or apolipoprotein A-I and B levels
Kojima et al., J Cell Biol 1991
:
Lipoprotein (a) inhibits the generation of
transforming growth factor beta : an endogenous inhibitor of smooth muscle cell migration
Edelberg et al., Blood Coagul Fibrinolysis 1991
:
Lipoprotein(a) inhibits
plasminogen activation in a template dependent manner
McConathy et al., Prog Lipid Res 1991
:
Since Apo(a) also has an affinity for ApoB-Lp, enhanced binding of
Apo(a) to the arterial wall could
increase the accumulation of
LDL in the matrix and thus promote the development of cardiovascular disease
Russo et al., Eur J Nutr 2008
:
was to evaluate the
effects of inulin enriched
pasta on lipid profile and on
Lipoprotein(a) in young healthy subjects
Tascilar et al., J Neurol Sci 2009
(Atherosclerosis...) :
However, in the
presence of apoE/E4 allele, increased low-density lipoprotein cholesterol ( LDL-chol ),
apolipoprotein B (apoB) and Lp(a) levels and in the presence of apo E/E3 allele, only
Lp(a) levels were determined as risk factors
Singla et al., International journal of diabetes in developing countries 2009
:
The elevated
Lp(a) levels do not reflect the glycemic status and are also
independent of increase in
LDL : HDL ratio suggesting different metabolic pathways and the genetic connection for LDL and Lp(a)
Loscalzo et al., Arteriosclerosis 1990
:
Lipoprotein(a) , fibrin binding, and
plasminogen activation
Goswami et al., Clin Biochem 2012
(Coronary Artery Disease...) :
Apolipoprotein-A ( Apo-AI ) and Apolipoprotein-B (Apo-B) were estimated and small dense
LDL was
derived mathematically
Goldberg et al., J Biol Chem 1990
:
Lipoprotein ApoC-II
activation of
lipoprotein lipase
Babaahmadi Rezaei et al., Iran Biomed J 2013
:
Compare the
Effect of Eicosapentaenoic Acid and Oxidized Low-Density
Lipoprotein on the Expression of
CD36 and Peroxisome Proliferator Activated Receptor Gamma
Edelberg et al., Biochemistry 1989
:
Lipoprotein a
inhibits streptokinase mediated activation of human
plasminogen
Herrmann et al., Med Klin (Munich) 1989
(Coronary Artery Disease) :
In 22 of the 32 patients
lipoprotein Lp ( a ) was
reduced significantly by 25.0 %,
apolipoprotein ( apo ) B by 11.4 %, apo A I by 7.8 %, triglycerides by 38.3 %, and cholesterol by 12.3 %
Winyard et al., Free Radic Res Commun 1989
(Arthritis, Rheumatoid) :
Lipoprotein oxidation and
induction of
ferroxidase activity in stored human extracellular fluids
Crane et al., Mol Cell Biochem 1983
(Liver Neoplasms, Experimental) :
Lipoprotein synthesis is stimulated by fatty acids and is
inhibited by
albumin and other macromolecules
Bröijersén et al., Eur J Clin Invest 1994
(Hyperlipoproteinemia Type II) :
Lp(a)-levels were
reduced by
LDL-apheresis and elevated by pravastatin treatment
Durovic et al., J Biol Chem 1994
:
We also studied the
effect of
r-apo(a) on the interaction of the monoclonal antibody MB47 with normal and mutant
apoB-100
Mims et al., Chem Phys Lipids 1994
:
In our studies we also noted that
Lp[a ] often
enhanced binding of
125I-LDL by fibroblasts
Pursiainen et al., Chem Phys Lipids 1994
(Arteriosclerosis) :
Furthermore, activated
R-apo(a) caused degradation of
125I-LDL ... The results show that
apo(a) is activated in the
presence of
LDL , and that this activation leads to proteolytic modification of LDL ... The
induction of
apo(a) proteolytic activity by
LDL suggests a novel mechanism whereby Lp(a) may be atherogenic
Edelberg et al., Chem Phys Lipids 1994
(Arteriosclerosis) :
Lipoprotein (a) regulates
plasmin generation and inhibition
Tonstad et al., Metabolism 1996
(Hyperlipoproteinemia Type II) :
We conclude that the effect of growth hormone on LDL cholesterol levels in FH is less than expected, based on its LDL-catabolic effects, and is counteracted by profound increases in
Lp(a) levels,
resulting in unchanged levels of
apolipoprotein B
Kostner et al., Eur J Clin Invest 1997
(Hypercholesterolemia) :
LDL-apheresis led to a reduction of plasma
Lp(a) by 75 % and a concomitant immediate reduction of urinary apo(a) by 45 %
Hofer et al., J Lipid Res 1997
(Carcinoma, Hepatocellular) :
LDL mediated interaction of
Lp[a ] with HepG2 cells : a novel fluorescence microscopy approach ... Quantification of the amount of fluorescent lipoprotein associated with the cell surface at 4 degrees C showed that binding of
Lp[a ] was increased in the
presence of
LDL under these conditions, probably via formation of an Lp[a ] -LDL complex
Takami et al., Circulation 1998
:
Lipoprotein(a) enhances the expression of
intercellular adhesion molecule-1 in cultured human umbilical vein endothelial cells
Netea et al., Infect Immun 1998
:
Lipoprotein(a) inhibits lipopolysaccharide induced
tumor necrosis factor alpha production by human mononuclear cells
Wooten et al., J Immunol 1998
:
Lipoprotein mediated
induction of nuclear factor-kappaB nuclear translocation and production of IL-8 and
IL-6 in HUVEC was enhanced in the presence of serum or soluble rCD14 ...
Lipoprotein mediated
induction of nuclear factor-kappaB nuclear translocation and production of
IL-8 and IL-6 in HUVEC was enhanced in the presence of serum or soluble rCD14
Allen et al., FASEB J 1998
(Arteriosclerosis...) :
The
involvement of the
LDL and VLDL receptors in
Lp(a) activation of HCAEC were ruled out since Lp(a) induction of adhesion molecules was not prevented by an antibody ( IgGC7 ) to the LDL receptor or by receptor activating protein, an antagonist of ligand binding to the VLDL receptor