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PLCG1 — RHOA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RHOA — PLCG1 (physical association, affinity chromatography technology) Thodeti et al., Biochem J 2002*
• IRef Biogrid Interaction: RHOA — PLCG1 (direct interaction, pull down) Thodeti et al., Biochem J 2002*
• IRef Hprd Interaction: RHOA — PLCG1 (in vitro) Thodeti et al., Biochem J 2002*
• IRef Hprd Interaction: RHOA — PLCG1 (in vivo) Thodeti et al., Biochem J 2002*
• IRef Ophid Interaction: RHOA — PLCG1 (aggregation, confirmational text mining) Thodeti et al., Biochem J 2002*
• IRef Ophid Interaction: RHOA — PLCG1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Thodeti et al., Biochem J 2002 (Calcium Signaling) : We also found that, within 15 s, activation of RhoA by LTD4 led to an increased association of RhoA with G-protein betagamma ( Gbetagamma ) and phospholipase C-gamma1 ( PLC-gamma1 ) in the plasma membrane, as evidenced by the results of co-immunoprecipitation, glutathione S-transferase (GST) pulldown assays, and confocal microscopy
Piechulek et al., J Biol Chem 2005 : PLCgamma(2), but not PLCgamma(1) , was markedly activated in intact cells by constitutively active Rac1 ( G12V ), Rac2 ( G12V ), and Rac3 ( G12V ) but not by Cdc42 ( G12V ) and RhoA ( G14V )