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IL1A — PTPN11

Text-mined interactions from Literome

Wang et al., J Biol Chem 2005 : IL-1 promoted phosphorylation of SHP-2 and PLCgamma1 ... BAPTA/AM ( 1,2-bis ( 2-aminophenoxy ) ethane-N, N,N ', N'-tetraacetic acid tetrakis ( acetoxymethyl ester ) ) blocked IL-1 induced phosphorylation of SHP-2 and PLCgamma1, indicating mutually dependent interactive roles for Ca ( 2+ ), SHP-2, and PLCgamma1 in IL-1 signaling
Herrera Abreu et al., J Cell Physiol 2006 : Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions
Wang et al., J Biol Chem 2010 : Interactions between SHP-2 and PTPalpha, recruitment of SHP-2 to focal adhesions, IL-1 induced ERK activation , and MMP3 expression were all blocked by point mutations in the phosphatase domains of PTPalpha