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PTBP1 — SHC1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of 168 proteins Blagoev et al., Nat Biotechnol 2003
• IRef Intact Interaction: Complex of 228 proteins (association, pull down) Blagoev et al., Nat Biotechnol 2003

Text-mined interactions from Literome

van der Geer et al., Oncogene 1999 : A triple substitution of the -5, -8 and -9 residues relative to Tyr 960 of the IR to the corresponding amino acids found in the Shc PTB domain binding site of TrkA results in even stronger binding of the IR to Shc in vivo
Sharma et al., Mol Cell Biol 1997 : In both cell types, overexpression of either the PTB or the SAIN protein caused a significant decrease in insulin induced tyrosine phosphorylation of IRS-1 and Shc proteins, IRS-1 associated phosphatidylinositol 3-kinase (PI 3-K) enzymatic activity, p70s6k activation, and p44 and p42 mitogen activated protein kinase ( MAPK ) phosphorylation