◀ Back to PARP1
NOS2 — PARP1
Text-mined interactions from Literome
Hassa et al., J Biol Chem 2001
:
Finally, we showed that
PARP-1 is
activating the natural inducible
nitric-oxide synthase and P-selectin promoter in a kappa B-dependent manner upon stimulation of the cells with inflammatory stimuli or cotransfection of p65
Wang et al., Ann N Y Acad Sci 2003
(Disease Models, Animal...) :
The mechanisms of MPTP induced neurotoxicity are not yet fully understood but involve activation of N-methyl-D-aspartate ( NMDA ) receptors by glutamate, production of NO by nNOS and
iNOS , oxidative injury to DNA, and
activation of the DNA damage sensing enzyme poly ( ADP-ribose ) polymerase (
PARP )
Nakajima et al., J Biol Chem 2004
(Inflammation) :
PARP-1 inhibitors and the antisense RNA for PARP-1 mRNA
suppressed lipopolysaccharide (LPS) induced expression of tumor necrosis factor-alpha and inducible
nitric-oxide synthase , suggesting that PARP-1 activity has a critical role in synthesis
Penberthy et al., Curr Drug Metab 2007
(Autoimmune Diseases) :
Chronic elevation of TNFalpha leading to necrotic events by NAD depletion in autoimmune disease likely occurs via combination of persistent IDO activation and
iNOS-peroxynitrate activation of
PARP1 both of which deplete NAD
Kujundzić et al., Immunol Lett 2008
:
Inhibition of poly ( ADP-ribose ) polymerase (
PARP ), a nuclear enzyme involved in DNA repair, replication and transcription, which cleaves NAD into nicotinamide and ADP-ribose, down
regulated iNOS gene transcription and NO production in ChIFN-gamma stimulated HD11 cells
von Lukowicz et al., Cardiovasc Res 2008
(Atherosclerosis...) :
PARP inhibition or PARP1 deletion
reduced PARP activity and diminished expression of inducible
nitric oxide synthase , vascular cell adhesion molecule-1, and P- and E-selectin
Naura et al., Eur Respir J 2009
(Eosinophilia) :
iNOS expression was
required for oxidative DNA damage and
PARP-1 activation upon allergen challenge ...
PARP-1 was
required for
iNOS expression and protein nitration, and this requirement was connected to nuclear factor-kappaB
Huang et al., Biochem Biophys Res Commun 2009
(Disease Models, Animal...) :
Minocycline repressed the expression of TNF-alpha, IL-1beta, and
iNOS , decreased the apoptotic index, and
inhibited poly(ADP-ribose) polymerase-1 ( PARP-1 ) activity in the mouse small intestine
Mittal et al., Mol Cell Biochem 2011
(Respiratory Distress Syndrome, Adult) :
Therefore, surfactant may regulate lung homeostasis by neutralizing acidic microenvironment in inflammatory lesions that leads to the
upregulation of
iNOS activity through the activation of NF-?B pathway and by
PARP activation
Qin et al., Biochim Biophys Acta 2013
(Inflammation) :
Moreover,
PARP-1 inhibition
attenuated LSS induced
iNOS and ICAM-1 upregulation by inhibiting nuclear factor kappa B ( NF-?B ) nuclear translocation and activity, with a reduced NF-?B phosphorylation
Czapski et al., Neurochem Int 2013
(Inflammation) :
PARP activity
plays a role in regulation of expression of
iNOS , the main enzyme responsible for oxidative/nitrosative stress in SIR