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KCNH4 — PARP1

Text-mined interactions from Literome

Garcia et al., Mol Cell Biol 2001 : Indeed, ( i ) in cells expressing wild-type or mutant Mpl, TPO induced Ras and Rap1 activation correlates with early and sustained phases of ERK signal, respectively ; ( ii ) interfering mutants of Ras and Rap1 both inhibit ERK kinase activity and ERK dependent Elk1 transcriptional activation in response to TPO ; ( iii ) the kinetics of activation of Raf-1 and B-Raf by TPO follow those of Ras and Rap1, respectively ; ( iv ) RasV12 mediated Elk1 activation was modulated by the wild type or interfering mutants of Raf-1 but not those of B-Raf ; ( v ) Elk1 activation mediated by a constitutively active mutant of Rap1 ( Rap1V12 ) is potentiated by B-Raf and inhibited by an interfering mutant of this kinase
Karhoff et al., Neuroendocrinology 2007 (Digestive System Neoplasms...) : Overexpression of Rap1 and B-Raf activated MAPK extracellular dependent kinase (ERK) ERK-2 and ERK dependent transcription factor Elk-1 in neuroendocrine cell lines Bon and INS-1